Evidence map›Paper›PMID 36200788›Full record

ReviewThe oncologist2023

The Value of Phenotypic Precision Medicine in Prostate Cancer.

Nathan M Hawkey, Amanda Broderick, Daniel J George, Oliver Sartor, Andrew J Armstrong

Open access · goldAbstract readReview
In one paragraph

Review in The oncologist, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. In Regard to Trotter et al.Advances in radiation oncology · 2024
    Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Nathan M HawkeyDepartment of Medicine, Division of Medical Oncology, Duke University School of Medicine, Durham, NC, USA.
Amanda BroderickDepartment of Medicine, Division of Medical Oncology, Duke University School of Medicine, Durham, NC, USA.
Daniel J GeorgeDepartment of Medicine, Division of Medical Oncology, Duke University School of Medicine, Durham, NC, USA.
Oliver SartorTulane Cancer Center, Division of Genitourinary Oncology, New Orleans, LA, USA.
Andrew J ArmstrongDepartment of Medicine, Division of Medical Oncology, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0001-7012-1754
Duke University · US

Funding

Targeting convergent oncogenic signaling during AR inhibition to overcome metastasis and immune evasion in prostate cancerR01CA233585 · NCI · DUKE UNIVERSITY · PI ARMSTRONG, ANDREW J · 2019 to 2023
$2.2M
Preparing Genetic Counselors for Genomic Medicine ResearchT32HG008955 · NHGRI · DUKE UNIVERSITY · PI COONEY, KATHLEEN A, HAGA, SUSANNE · 2017 to 2021
$2.0M
NCI NIH HHS R01 CA233585NHGRI NIH HHS T32 HG008955
6 · The paper itself

Abstract

Prostate cancer is the most common cancer among men and the second leading cause of cancer-related death. For patients who develop metastatic disease, tissue-based and circulating-tumor-based molecular and genomic biomarkers have emerged as a means of improving outcomes through the application of precision medicine. However, the benefit is limited to a minority of patients. An additional approach to further characterize the biology of advanced prostate cancer is through the use of phenotypic precision medicine, or the identification and targeting of phenotypic features of an individual patient's cancer. In this review article, we will discuss the background, potential clinical benefits, and limitations of genomic and phenotypic precision medicine in prostate cancer. We will also highlight how the emergence of image-based phenotypic medicine may lead to greater characterization of advanced prostate cancer disease burden and more individualized treatment approaches in patients.

Indexed as

Prostatic NeoplasmsProstatic Neoplasms, Castration-ResistantBiomarkers, TumorHumansMalePrecision MedicineBiomarkers, Tumorimage-based biomarkersmetastatic castrate-resistant prostate cancerphenotypic precision medicineprecision medicineprostate-specific membrane antigen (PSMA)radiopharmaceuticals

Identifiers

PMID36200788
PMCPMC9907055
OpenAlexW4302305158

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.