Evidence map›Paper›PMID 36200403›Full record

Trial reportClinical gerontologist

Pilot RCT Testing A Mailing About Sleeping Pills and Cognitive Behavioral Therapy for Insomnia: Impact on Benzodiazepines and Z-Drugs.

Selene S Mak, Cathy A Alessi, Christopher N Kaufmann, Jennifer L Martin, Michael N Mitchell, Christi Ulmer, Hillary D Lum, Michaela S McCarthy, Jason P Smith, Constance H Fung

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Clinical gerontologist. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 3 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 3 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Observational
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 1 country.

Selene S MakGeriatric Research, Education, and Clinical Center, VA Greater Los Angeles Healthcare System, North Hills, California, USA.
Cathy A AlessiGeriatric Research, Education, and Clinical Center, VA Greater Los Angeles Healthcare System, North Hills, California, USA.
Christopher N KaufmannDepartment of Health Outcomes and Biomedical Informatics, University of Florida College of Medicine, Gainesville, Florida, USA.
Jennifer L MartinGeriatric Research, Education, and Clinical Center, VA Greater Los Angeles Healthcare System, North Hills, California, USA.
Michael N MitchellGeriatric Research, Education, and Clinical Center, VA Greater Los Angeles Healthcare System, North Hills, California, USA.
Christi UlmerDepartment of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA.
Hillary D LumDivision of Geriatric Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, California, USA.
Michaela S McCarthyDenver-Seattle Center of Innovation for Veteran-Centered and Value-Driven Care (COIN), VA Eastern Colorado Health Care System, Denver, California, USA.
Jason P SmithVA Pharmacy Benefits Management, VA Rocky Mountain Network, Glendale, California, USA.
Constance H FungGeriatric Research, Education, and Clinical Center, VA Greater Los Angeles Healthcare System, North Hills, California, USA.
Geriatric Research Education and Clinical Center · USDuke University · USFlorida College · USUniversity of California, Los Angeles · USUniversity of Colorado Denver · USVA Eastern Colorado Health Care System · USVA Greater Los Angeles Healthcare System · USVA Rocky Mountain Network · US

Funding

Sleep health in special populationsK24HL143055 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARTIN, JENNIFER L · 2018 to 2025
$898k
Sedative-Hypnotic Use Patterns and Risk for Cognitive Decline and Alzheimer's DiseaseK01AG061239 · NIA · UNIVERSITY OF FLORIDA · PI KAUFMANN, CHRISTOPHER NORFLEET · 2019 to 2023
$656k
The Efficacy of Masked Tapering on Discontinuation of Hypnotics in Older VeteransI01HX002166 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI FUNG, CONSTANCE · 2019 to 2025
–
HSR&D Research Career Scientist AwardIK6HX003160 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI MARTIN, JENNIFER L · 2020 to 2025
–
HSRD VA I01 HX002166HSRD VA IK6 HX003160NHLBI NIH HHS K24 HL143055NIA NIH HHS K01 AG061239
6 · The paper itself

Abstract

objectivesThe aim is to pilot a low-touch program for reducing benzodiazepine receptor agonist (BZRA; benzodiazepines, z-drugs) prescriptions among older veterans.

methodsPilot randomized controlled trial consists of 2,009 veterans aged ≥ 65 years who received BZRA prescriptions from a Veterans Health Administration pharmacy (Colorado or Montana) during the prior 18 months. Active: Arm 1 was a mailed brochure about BZRA risks that also included information about a free, online cognitive behavioral therapy for the insomnia (CBTI) program. Arm 2 was a mailed brochure (same as arm 1) and telephone reinforcement call. Control: Arm 3 was a mailed brochure without insomnia treatment information. Active BZRA prescriptions at follow-up (6 and 12 months) were measured.

resultsIn logistic regression analyses, the odds of BZRA prescription at 6- and 12-month follow-ups were not significantly different for arm 1 or 2 (active) versus arm 3 (control), including models adjusted for demographics and prescription characteristics (

conclusionsAlthough we observed no differences in active BZRA prescriptions, this pilot study provides guidance for conducting a future study, indicating a need for a more potent intervention. A full-scale trial testing an optimized program would provide conclusive results. CLINICAL IMPLICATIONS: Mailing information about BZRA risks and CBTI did not affect BZRA prescriptions.

Indexed as

Cognitive Behavioral TherapySleep Aids, PharmaceuticalSleep Initiation and Maintenance DisordersAgedBenzodiazepinesHumansPharmaceutical PreparationsPilot ProjectsBenzodiazepinesPharmaceutical PreparationsSleep Aids, PharmaceuticalagingBenzodiazepinedeprescribinginsomniamortalityolder adults

Identifiers

PMID36200403
PMCPMC10076445
OpenAlexW4302290764

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.