ArticleEnvironmental microbiology2022
Fitness costs of Wolbachia shift in locally-adapted Aedes aegypti mosquitoes.
Article in Environmental microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Wolbachia wMel and wAlbB strains differentially impact the vector competence of Aedes aegypti with a Brazilian genetic background for DENV-1 virus.Parasites & vectors · 2026Article
- Structure and Diversity of the Microbiome in Amazonian Sand Flies: Insights into Vector-Microbe Interactions.Microbial ecology · 2026Article
- Wolbachia introgression in Rio de Janeiro remains at sub-optimal levels 30 months after its decline: challenges in the sustainability of wMel interventions for dengue control.Memorias do Instituto Oswaldo Cruz · 2026Article
- Improving Wolbachia-based control programs in urban settings: Insights from spatial modeling.PLoS neglected tropical diseases · 2025Article
- Ecological dynamics of field Aedes albopictus populations under Wolbachia-mediated suppression.Infectious diseases of poverty · 2025Article
- Article
- Assessing the direct and spillover protective effectiveness of Wolbachia-mediated introgression to combat dengue.EBioMedicine · 2024Article
- Post-release monitoring pathway for the deployment of gene drive-modified mosquitoes for malaria control in Africa.Malaria journal · 2024Article
- Article
- Article
- Aedes aegypti microbiome composition covaries with the density of Wolbachia infection.Microbiome · 2023Article
- Quantifying Fitness Costs in Transgenic Aedes aegypti Mosquitoes.Journal of visualized experiments : JoVE · 2023Article
- Using models and maps to inform Target Product Profiles and Preferred Product Characteristics: the example ofGates open research · 2023Article
- Fitness costs of Wolbachia shift in locally-adapted Aedes aegypti mosquitoes.Environmental microbiology · 2022Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aedes aegypti mosquito eggs can remain quiescent for many months before hatching, allowing populations to persist through unfavourable conditions. A. aegypti infected with the Wolbachia strain wMel have been released in tropical and subtropical regions for dengue control. wMel reduces the viability of quiescent eggs, but this physiological cost might be expected to evolve in natural mosquito populations that frequently experience stressful conditions. We found that the cost of wMel infection differed consistently between mosquitoes collected from different locations and became weaker across laboratory generations, suggesting environment-specific adaptation of mosquitoes to the wMel infection. Reciprocal crossing experiments show that differences in the cost of wMel to quiescent egg viability were mainly due to mosquito genetic background and not Wolbachia origin. wMel-infected mosquitoes hatching from long-term quiescent eggs showed partial loss of cytoplasmic incompatibility and female infertility, highlighting additional costs of long-term quiescence. Our study provides the first evidence for a shift in Wolbachia phenotypic effects following deliberate field release and establishment and it highlights interactions between Wolbachia infections and mosquito genetic backgrounds. The unexpected changes in fitness costs observed here suggest potential tradeoffs with undescribed fitness benefits of the wMel infection.
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