ArticleAnnals of geriatric medicine and research2022
Functional Constipation is Associated with a Decline in Word Recognition 2 Years Later in Community-Dwelling Older Adults: The Korean Frailty and Aging Cohort Study.
Article in Annals of geriatric medicine and research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.
- Physical Activity and Cognitive Decline Among Older Adults: A Systematic Review and Meta-Analysis.JAMA network open · 2024Pooled it
- Best Practice to Prevent Constipation in People Living With Dementia: A Scoping Review.International journal of older people nursing · 2025Article
- Beyond the gut: The overlooked impact of constipation on functional mobility and quality of life in community-dwelling elders - a cross-sectional study.Geriatrics & gerontology international · 2025Article
- The Association Between Constipation and Positron Emission Tomography and Blood-Based Biomarkers in Older Cognitively Unimpaired Adults with Higher Amyloid-β Burden.Neurology and therapy · 2024Article
- Investigating Frailty, Polypharmacy, Malnutrition, Chronic Conditions, and Quality of Life in Older Adults: Large Population-Based Study.JMIR public health and surveillance · 2024Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundConsumption and cognitive impairment are the most common health problems among older adults. This study aimed to determine the effects of functional constipation on cognitive decline in community-dwelling older adults.
methodsThis was a 2-year longitudinal analysis of Korean Frailty and Aging Cohort Study data, including 851 community-dwelling residents who participated in both the baseline and follow-up surveys. A neuropsychological test, the Consortium to Establish a Registry for Alzheimer's Disease Assessment Battery (CERAD-K), and the Korean version of the Frontal Assessment Battery (FAB) were used to evaluate cognitive function. Functional constipation was defined according to the ROME IV criteria. An analysis of covariance was used to identify the association between functional constipation and cognitive decline.
resultsAmong the 851 participants, 8.9% had functional constipation. The patients in the constipation group were more likely to have low physical activity (15.8% vs. 8.8%), polypharmacy (61.8% vs. 45.5%), and depression (30.3% vs. 17.4%) than the non-constipation group. After adjusting for potential confounding factors, including age, sex, education years, low physical activity, polypharmacy, type 2 diabetes mellitus, depression, and baseline Cognitive Function Test score, the mean changes in Word Recognition test scores from 2018 to 2020 were -0.07 and -0.54 in the non-constipation and constipation groups, respectively (p=0.007). Other cognitive function tests (Mini-Mental State Examination, word list memory, word list recall, digit span, trail-making test, and FAB) did not show any difference in decline between the two groups (p>0.05).
conclusionsFunctional constipation at baseline was associated with a decline in word recognition after 2 years.
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Registered trials
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