SynthesisActa paediatrica (Oslo, Norway : 1992)2023
Somatic growth in single ventricle patients: A systematic review and meta-analysis.
Synthesis in Acta paediatrica (Oslo, Norway : 1992), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Somatic growth in single ventricle patients: A systematic review and meta-analysis.Acta paediatrica (Oslo, Norway : 1992) · 2023Pooled it
- Factors Influencing Weight Gain at Different Stages of the Fontan Pathway for Children with Functionally Single Ventricle Heart Disease.Pediatric cardiology · 2026Article
- What Limits Cardiorespiratory Fitness in Adolescents with Fontan Circulation: An Integrated Hemodynamic and Pulmonary Perspective.Pediatric cardiology · 2026Article
- Early Experience with the First Canadian Paediatric Fontan Long-Term Follow-up Clinic.Pediatric cardiology · 2026Article
- Growth in pediatric heart transplantation.JHLT open · 2026Article
- Severity of Congenital Heart Defects Affects Long-Term Somatic Development.Pediatric cardiology · 2026Article
- Comment on "Severity of Congenital Heart Defects Affects Long-Term Somatic Development".Pediatric cardiology · 2026Article
- Systemic Changes in Adults With a Fontan Circulation: Insights From the Plasma Proteome.Journal of the American Heart Association · 2025Article
- Growth Characteristics at Time of Fontan Procedure and Their Association with Long-Term Outcomes.The Journal of pediatrics · 2025Article
- Growth pattern of children with congenital heart disease before and after open heart surgery.Frontiers in pediatrics · 2025Article
- Pathogenesis and Surgical Treatment of Congenitally Corrected Transposition of the Great Arteries (ccTGA): Part III.Journal of clinical medicine · 2024Review
- Article
- Noninvasive Advanced Cardiovascular Magnetic Resonance-Derived Fontan Hemodynamics Are Associated With Reduced Kidney Function But Not Albuminuria.Journal of the American Heart Association · 2024Article
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Authors and funding
9 authors.
Funding
Abstract
aimTo map somatic growth patterns throughout Fontan palliation and summarise evidence on its key modifiers.
methodsDatabases were searched for relevant articles published from January 2000 to December 2021. Height and weight z scores at each time point (birth, Glenn procedure, Fontan procedure and >5 years after Fontan completion) were pooled using a random effects meta-analysis. A random effects meta-regression model was fitted to model the trend in z scores over time.
resultsNineteen studies fulfilled eligibility criteria, yielding a total of 2006 participants. The z scores for height and weight were markedly reduced from birth to the interstage period, but recovered by about 50% following the Glenn procedure. At >10 years after the Fontan procedure, the z scores for weight seemed to normalise despite persistent lower height, resulting in increased body mass index. The review revealed a number of modifiers of somatic growth, including aggressive nutritional management, timing of Glenn/Fontan, prompt resolution of complications and obesity prevention programmes in adolescence and adulthood.
conclusionThis review mapped the somatic growth of single ventricle patients and summarised key modifiers that may be amendable to improvement. These data provide guidance on strategies to further optimise somatic growth in this population and may serve as a benchmark for clinical follow-up.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.