Evidence map›Paper›PMID 36200140›Full record

ArticlePhysiological reports2022

QT

Hongwei Cheng, Ian Charles, Andrew F James, Ana P Abdala, Jules C Hancox

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. QTPhysiological reports · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hongwei ChengSchool of Physiology, Pharmacology and Neuroscience, University Walk, Bristol, UK.
Ian CharlesSchool of Physiology, Pharmacology and Neuroscience, University Walk, Bristol, UK.
Andrew F JamesSchool of Physiology, Pharmacology and Neuroscience, University Walk, Bristol, UK.ORCID 0000-0002-2035-9489
Ana P AbdalaSchool of Physiology, Pharmacology and Neuroscience, University Walk, Bristol, UK.ORCID 0000-0001-6566-9205
Jules C HancoxSchool of Physiology, Pharmacology and Neuroscience, University Walk, Bristol, UK.ORCID 0000-0002-2055-6482
University of Bristol · GB

Funding

British Heart Foundation PG/16/55/32277
6 · The paper itself

Abstract

Rett Syndrome (RTT) is a congenital, X-chromosome-linked developmental disorder characterized by developmental delay, dysautonomia, and breathing irregularities. RTT is also associated with sudden death and QT intervals are prolonged in some RTT patients. Most individuals with RTT have mutations in the MECP2 gene. Whilst there is some evidence for QT prolongation in mouse models of RTT, there is comparatively little information on how loss of Mecp2 function affects ventricular action potentials (APs) and, to-date, none on ventricular APs from female RTT mice. Accordingly, the present study was conducted to determine ECG and ventricular AP characteristics of Mecp2

Indexed as

Long QT SyndromeRett SyndromeAction PotentialsAnimalsApneaDisease Models, AnimalFemaleMethyl-CpG-Binding Protein 2MiceMice, KnockoutMecp2 protein, mouseMethyl-CpG-Binding Protein 2action potentialAPD90eleclazineGS-6615MECP2QT intervalranolazinerepolarizationRett syndromeRTT

Identifiers

PMID36200140
PMCPMC9535259
OpenAlexW4302287512

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.