Evidence map›Paper›PMID 36200047›Full record

ArticleFrontiers in cell and developmental biology2022

The Piwil1 N domain is required for germ cell survival in Atlantic salmon.

Almeida F L, Skaftnesmo K O, Andersson E, Kleppe L, Edvardsen R B, Norberg B, Fjelldal P G, Hansen T J, Schulz R W, Wargelius A

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Generation of IgMScientific reports · 2025
    Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

Almeida F LResearch Group Reproduction and Developmental Biology, Institute of Marine Research, Bergen, Norway.
Skaftnesmo K OResearch Group Reproduction and Developmental Biology, Institute of Marine Research, Bergen, Norway.
Andersson EResearch Group Reproduction and Developmental Biology, Institute of Marine Research, Bergen, Norway.
Kleppe LResearch Group Reproduction and Developmental Biology, Institute of Marine Research, Bergen, Norway.
Edvardsen R BResearch Group Reproduction and Developmental Biology, Institute of Marine Research, Bergen, Norway.
Norberg BResearch Group Reproduction and Developmental Biology, Institute of Marine Research, Bergen, Norway.
Fjelldal P GResearch Group Reproduction and Developmental Biology, Institute of Marine Research, Bergen, Norway.
Hansen T JResearch Group Reproduction and Developmental Biology, Institute of Marine Research, Bergen, Norway.
Schulz R WResearch Group Reproduction and Developmental Biology, Institute of Marine Research, Bergen, Norway.
Wargelius AResearch Group Reproduction and Developmental Biology, Institute of Marine Research, Bergen, Norway.
Norwegian Institute of Marine Research · NOBrazilian Agricultural Research Corporation · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genetic introgression of farmed salmon into wild populations can damage the genetic integrity of wild stocks and is therefore considered as an environmental threat. One possible solution is to induce sterility in farmed salmon. We have searched for proteins potentially essential for germline survival in Atlantic salmon. One of these is the argonaute protein Piwil1, known to be required for germ cell survival. To examine Piwil1 function in salmon, we induced indels in the N domain by CRISPR-Cas9. The encoded domain is present in all vertebrate Piwi proteins and has been linked to Tdrd1 protein interaction and PAZ lobe structure. The F0 founder generation of

Indexed as

argonaute protein (AGO)CRISPR/Cas9fish sterilitygermlinespermatogenesis

Identifiers

PMID36200047
PMCPMC9527287
OpenAlexW4296351475

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.