Evidence map›Paper›PMID 36200012›Full record

ArticleEcancermedicalscience2022

A comparison of dosimetric parameters in high-dose-rate intracavitary brachytherapy using tandem and ring applicators: is the combination of a rectal retractor and radio-opaque vaginal packing better than rectal retractor alone for rectum sparing in cervical cancer?

Siddharth Vats, Shabnum Thakur, Mukesh Sharma, Manish Gupta, Lalit Chandrakant, Muninder Negi, Swati Verma, Anup Negi, Vivek Kumar, Parul Sharma and 1 more

Open access · goldAbstract read
In one paragraph

Article in Ecancermedicalscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
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  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Siddharth VatsDepartment of Radiotherapy & Oncology, IGMC Shimla, Himachal Pradesh, 171001, India.
Shabnum ThakurDepartment of Radiotherapy & Oncology, IGMC Shimla, Himachal Pradesh, 171001, India.
Mukesh SharmaDepartment of Radiotherapy & Oncology, Dr. YSP Govt. Medical College, Nahan, Himachal Pradesh, 173001, India.
Manish GuptaDepartment of Radiotherapy & Oncology, IGMC Shimla, Himachal Pradesh, 171001, India.
Lalit ChandrakantDepartment of Radiotherapy & Oncology, IGMC Shimla, Himachal Pradesh, 171001, India.
Muninder NegiDepartment of Radiotherapy & Oncology, RP Govt. Medical College, Tanda, Kangra, Himachal Pradesh, 176001, India.
Swati VermaDepartment of Radiotherapy & Oncology, AIIMS Rishikesh, Rishikesh, Uttarakhand, 249203, India.
Anup NegiDepartment of Radiotherapy & Oncology, IGMC Shimla, Himachal Pradesh, 171001, India.
Vivek KumarDepartment of Radiotherapy & Oncology, IGMC Shimla, Himachal Pradesh, 171001, India.
Parul SharmaDepartment of Radiotherapy & Oncology, IGMC Shimla, Himachal Pradesh, 171001, India.
Rattan Mahesh NegiDepartment of Radiotherapy & Oncology, IGMC Shimla, Himachal Pradesh, 171001, India.
Himachal Pradesh University · INAll India Institute of Medical Sciences Rishikesh

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To describe a novel packing technique of combining radio-opaque vaginal packing (VP) with rectal retractor (RR) blade to displace rectum and to compare the standard International Commission on Radiation Units & Measurements-38 (ICRU-38) rectal, bladder point doses and volume parameters with the conventional technique of using RR alone with tandem and ring (T&R) applicators in high-dose-rate (HDR) intracavitary brachytherapy (ICB) for cervical cancer. Materials and methods: A retrospective analysis of the treatment plans of a cohort of 24 consecutively treated patients with locally advanced cervical cancer was performed. All patients received external beam radiotherapy with a dose of 45-50.4 Gy, in fractions of 1.8-2 Gy, to the whole pelvis with concurrent weekly chemotherapy, followed by HDR-ICB. The treatment plans for each brachytherapy session using T&R applicators that these patients received were included for analysis. A total of 17 treatment plans in which the combination of RR and radio-opaque VP was used for rectum separation were included in the combination (RR+VP) group, and 21 treatment plans in which a RR alone was used were included in the conventional (RR) group. Results: The mean dose to the ICRU rectal point was 39.7% of the point A dose (range, 28.8%-50.4%; median 38.6%) in the RR+VP group and 52.7% (range, 46.9%-63.6%; median 51.7%) in the RR group. This 13% reduction in the mean dose to the ICRU rectal point was statistically significant ( Conclusion: Compared to the conventional use of a RR blade alone for rectum separation, combining a RR blade with radio-opaque VP significantly reduced the ICRU rectal point dose.

Indexed as

cervical cancerhigh dose rateintracavitary brachytherapyrectal sparingtandem and ring applicator

Identifiers

PMID36200012
PMCPMC9470171
OpenAlexW4290647867

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.