ArticleClinical interventions in aging2022
Age-Related Changes in Corneal Epithelial Thickness Measured with an Ultrasound Pachymeter.
Article in Clinical interventions in aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- Age-Related Changes in Differential Corneal Thickness and Their Correlation with With-the-Rule and Against-the-Rule Corneal Astigmatism.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Beyond the Cornea: Systemic Diseases and Their Impact on Endothelial Health-A Narrative Review.Journal of clinical medicine · 2026Review
- Epithelial Thickness Changes After Descemet Membrane Endothelial Keratoplasty (DMEK): An Observational Study.Journal of clinical medicine · 2026Article
- Age-related lncRNA alterations of SDHAP2_miR-17-5p/miR-20b-5p_RAB11FIP1 ceRNA network in donor-derived human limbal epithelial cells.Frontiers in cell and developmental biology · 2026Article
- Investigation of postmortem change in the human corneal epithelium via impression cytology.Scientific reports · 2025Article
- Effect of Age and Gender on Corneal Epithelial Thickness in Refractive Surgery Candidates.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Article
- Retinal and Corneal OCT Results of Patients Hospitalized and Treated in the Acute Phase of COVID-19.Journal of clinical medicine · 2024Article
- Transepithelial Photorefractive Keratectomy-Review.Vision (Basel, Switzerland) · 2024Review
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: There is increasing research on the aging process of the cornea and its effect on the corneal parameters measured objectively. Nevertheless, the association of corneal epithelial thickness (CET) with age has yet to be fully illustrated. Purpose: We aimed to measure CET in healthy subjects to determine its age-related variation by using an ultrasound device. Patients and Methods: A total of one hundred and three subjects were enrolled in this study and grouped according to age: Group < 30 years, 31-40 years, 41-50 years, 51-60 years, 61-70 years, and > 71 years. The CET and total central corneal thickness (CCT) of each subject were measured by the Sonogage Corneo-Gage Plus 2 (Cleveland, Ohio) ultrasound pachymeter. The relationships between thickness values, laterality, age groups, and gender were analyzed using the Jonckheere-Terpstra test. The Partial correlation test was employed to assess the effect of age on the CET and CCT. Results: The mean CET was 47.88±1.15μm, with no statistically significant gender-related difference between right and left eyes. In addition, the CCT difference detected between female and male eyes was insignificant. The difference in mean CET across age groups was statistically significant (p =0.029). The difference in mean CET of left eyes across age groups was statistically significant (p=0.031). The mean CET and left CET of the oldest group were significantly thinner than the younger groups. Conclusion: Ultrasound pachymeter of the corneal epithelium demonstrated that there was no correlation between age and CCT, or gender. The CET becomes thinner with age in the central zone in both genders and there is no difference between males and females. Based on these results, age has a negative effect on CET. These findings could offer further insight into age-related changes in the cornea.
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