Evidence map›Paper›PMID 36199973›Full record

ReviewNeuro-oncology advances

The abscopal effect: systematic review in patients with brain and spine metastases.

Dhiraj J Pangal, Benjamin Yarovinsky, Tyler Cardinal, David J Cote, Jacob Ruzevick, Frank J Attenello, Eric L Chang, Jason Ye, Josh Neman, Frances Chow and 1 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Dhiraj J PangalUSC Brain Tumor Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Benjamin YarovinskyUSC Brain Tumor Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Tyler CardinalUSC Brain Tumor Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0001-8277-6942
David J CoteUSC Brain Tumor Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Jacob RuzevickUSC Brain Tumor Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Frank J AttenelloUSC Brain Tumor Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Eric L ChangUSC Brain Tumor Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Jason YeUSC Brain Tumor Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Josh NemanUSC Brain Tumor Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Frances ChowUSC Brain Tumor Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Gabriel ZadaUSC Brain Tumor Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
University of Southern California · US

Funding

Southern California Clinical and Translational Science InstituteUL1TR001855 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Thomas A Buchanan, Michele D. Kipke · 2016 to 2026
$81.3M
Mentored Career DevelopmentKL2TR001854 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Elizabeth Rhea Erwin Burner, Amy Elizabeth West · 2016 to 2026
$9.0M
NCATS NIH HHS KL2 TR001854NCATS NIH HHS UL1 TR001855
6 · The paper itself

Abstract

Background: The abscopal effect is a rare phenomenon whereby local radiation induces a proposed immune-mediated anti-tumor effect at distant sites. Given the growing use of immunotherapies and systemic immune checkpoint inhibitors in neuro-oncologic practice, we aimed to review prior studies pertaining to this phenomenon in the context of tumor shrinkage both within the central nervous system as well as distant disease sites. Methods: A systematic review in accordance with the PRISMA guidelines was conducted to identify all studies which assessed the abscopal effect in patients with treated metastatic cancer to the brain and/or spine. Articles were included if they reported the abscopal effect in patients (case studies) or if the abscopal effect was explicitly analyzed in case series with cohorts of patients with metastatic brain or spine tumors. Laboratory investigations and clinical trials investigating new therapies were excluded. Results: Twenty reports met inclusion criteria [16 case reports, 4 case series ( Conclusions: Abscopal effects can occur following radiotherapy in patients with brain or spine metastases and is thought to be a result of increased anti-tumor immunity. The potential for immune checkpoint inhibitor therapy to be used in combination with radiotherapy to induce an abscopal effect is an area of active investigation.

Indexed as

abscopal effectbrain metastasislocal radiation with distant anti-tumor effectneuro-oncologyspine metastasis

Identifiers

PMID36199973
PMCPMC9529003
OpenAlexW4292510798

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.