ArticleNature aging2022
Cerebral amyloid angiopathy is associated with glymphatic transport reduction and time-delayed solute drainage along the neck arteries.
Erratum issuedOpen access · greenAbstract readLetter
In one paragraph
Article in Nature aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 55 papers.
0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 75 citations in OpenAlex.
- Article
- Novel Therapeutic Insights Into Alzheimer's Disease: Glymphatic System and Meningeal Lymphatic Vessels.Aging cell · 2026Review
- Fibronectin mediates APOE4-driven blood-brain barrier dysfunction in Alzheimer's disease.Nature aging · 2026Article
- Article
- Glymphatic Dysfunction, Brain Damage, and Clinical Disability in Spinocerebellar Ataxia Type 3.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- MR-AIV reveals in vivo brain-wide fluid flow with physics-informed AI.Science advances · 2026Article
- Robust MR-AIV: A Systematic Study of Robustness Improvement and Sensitivity Analysis of MR-AIV.bioRxiv : the preprint server for biology · 2026Article
- Glymphatic System Dysfunction in Central Nervous System Diseases.CNS neuroscience & therapeutics · 2026Review
- Functional border-associated macrophages limit Alzheimer's Disease progression.bioRxiv : the preprint server for biology · 2026Article
- Amyloidosis of bridging veins is a pathologic feature of Alzheimer's disease.The Journal of experimental medicine · 2026Article
- Barrier-Immune Gating Failure in Gut-Brain Neuroinflammation: A Working Hypothesis and Conceptual Framework.Behavioural neurology · 2026Review
- Region-specific drivers of CSF mobility measured with MRI in humans.Nature neuroscience · 2025Article
- Age-dependent brain responses to mechanical stress determine resilience in a chronic lymphatic drainage impairment model.The Journal of clinical investigation · 2025Article
- Morphology of the glymphatic and meningeal lymphatic structures of the bottlenose dolphin.Scientific reports · 2025Article
- MR-AIV revealsbioRxiv : the preprint server for biology · 2025Article
- Meningeal leukaemic aggregates as foci of cell expansion and chemoresistance in acute lymphoblastic leukaemia metastasis.Cellular oncology (Dordrecht, Netherlands) · 2025Article
- Article
- Meningeal lymphatic drainage: novel insights into central nervous system disease.Signal transduction and targeted therapy · 2025Review
- Cerebrospinal fluid flow within ventricles and subarachnoid space evaluated by velocity selective spin labeling MRI.NeuroImage · 2025Article
- Relationship between cerebrospinal fluid circulation markers, brain degeneration, and cognitive impairment in cerebral amyloid angiopathy.Frontiers in aging neuroscience · 2025Article
Corrections and comments
- Erratum issued
- Erratum issued
Authors and funding
14 authors at 5 institutions in 1 country.
Xinan Chen *Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, USA.ORCID http://orcid.org/0000-0002-2418-5041
Xiaodan Liu *Department of Anesthesiology, Yale School of Medicine, New Haven, CT, USA.
Sunil KoundalDepartment of Anesthesiology, Yale School of Medicine, New Haven, CT, USA.
Rena ElkinDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-2435-3399
Xiaoyue ZhuGeorge and Anne Ryan Institute for Neuroscience and the Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI, USA.
Brittany MonteDepartment of Anesthesiology, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-3060-5145
Feng XuGeorge and Anne Ryan Institute for Neuroscience and the Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI, USA.
Feng DaiYale Center for Analytical Sciences, Yale School of Public Health, New Haven, CT, USA.
Maysam PedramDepartment of Anesthesiology, Yale School of Medicine, New Haven, CT, USA.
Hedok LeeDepartment of Anesthesiology, Yale School of Medicine, New Haven, CT, USA.
Jonathan KipnisCenter for Brain Immunology and Glia, Department of Pathology and Immunology, Washington University, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-3714-517X
Allen TannenbaumDepartment of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, USA.ORCID http://orcid.org/0000-0002-0567-5256
William E Van NostrandGeorge and Anne Ryan Institute for Neuroscience and the Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI, USA.
Helene BenvenisteDepartment of Anesthesiology, Yale School of Medicine, New Haven, CT, USA. helene.benveniste@yale.edu.ORCID http://orcid.org/0000-0002-2887-6667
Yale University · USUniversity of Rhode Island · USStony Brook University · USMemorial Sloan Kettering Cancer Center · USWashington University in St. Louis · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MYale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MRobust workflow software for MRI tracking of glymphatic-lymphatic couplingR01AT011419 · NCCIH · YALE UNIVERSITY · PI BENVENISTE, HELENE D, KIPNIS, JONATHAN · 2021 to 2025
$3.6MCharacterizing the glymphatic peri-vascular connectome and its disruption in ADRF1AG053991 · NIA · YALE UNIVERSITY · PI BENVENISTE, HELENE D, NEDERGAARD, MAIKEN · 2016 to 2016
$3.4MNCATS NIH HHS UL1 TR001863NCCIH NIH HHS R01 AT011419NCI NIH HHS P30 CA008748NIA NIH HHS RF1 AG053991
Abstract
PubMed holds no abstract for this paper.
Indexed as
Alzheimer DiseaseCerebral Amyloid AngiopathyArteriesDrainageHumans
Identifiers
What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.