Evidence map›Paper›PMID 36199737›Full record

ArticlePrzeglad menopauzalny = Menopause review2022

Ghrelin, glucagon-like peptide-1, and peptide YY secretion in patients with and without weight regain during long-term follow-up after bariatric surgery: a cross-sectional study.

Charalampos Lampropoulos, Francesk Mulita, Theodoros Alexandrides, Dimitrios Kehagias, Dimitra Kalavrizioti, Konstantinos Albanopoulos, Neoklis Georgopoulos, Evangelos Papachristou, Ioannis Kehagias

Abstract read
In one paragraph

Article in Przeglad menopauzalny = Menopause review, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Charalampos LampropoulosIntensive Care Unit, Saint Andrew's General Hospital of Patras, Greece.
Francesk MulitaDepartment of General Surgery, Division of Bariatric and Metabolic Surgery, General University Hospital of Patras, Greece.
Theodoros AlexandridesDepartment of Internal Medicine, Division of Endocrinology, General University Hospital of Patras, Greece.
Dimitrios KehagiasDepartment of General Surgery, Division of Bariatric and Metabolic Surgery, General University Hospital of Patras, Greece.
Dimitra KalavriziotiDepartment of Nephrology and Renal Transplantation, General University Hospital of Patras, Greece.
Konstantinos Albanopoulos1 Propaedeutic Surgical Department, Medical School, National and Kapodistrian University of Athens, Hippocratio General Hospital of Athens, Greece.
Neoklis GeorgopoulosDepartment of Internal Medicine, Division of Endocrinology, General University Hospital of Patras, Greece.
Evangelos PapachristouDepartment of Nephrology and Renal Transplantation, General University Hospital of Patras, Greece.
Ioannis KehagiasDepartment of General Surgery, Division of Bariatric and Metabolic Surgery, General University Hospital of Patras, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Weight loss after bariatric surgery is attributed, at least in part, to the altered gastrointestinal (GI) hormone secretion, which is thought to be responsible for a number of beneficial metabolic effects. Material and methods: We conducted a cross-sectional study. Twelve patients who underwent laparoscopic sleeve gastrectomy (SG) and 20 patients who underwent a variant of biliopancreatic diversion with Roux-en-Y gastric bypass and long limbs (BPD/RYGB-LL) were evaluated ≥ 7 years postoperatively. Ghrelin, glucagon-like peptide-1 (GLP-1), and peptide YY (PYY) secretion were compared between patients with successful weight loss maintenance (WM group) and patients with weight regain (WR group). Results: In both types of surgery, standard liquid mixed meal (SLMM) ingestion did not result in significant changes in fasting GI hormone levels. Fasting ghrelin levels did not differ between the WM group and the WR group in both types of surgery. In SG patients, SLMM ingestion elicited greater suppression of ghrelin levels in the WM group (p = 0.032). No difference in GLP-1 secretion was observed between the 2 groups of patients in both types of surgery. When patients were examined, regardless of the type of bariatric surgery they had undergone, postprandial PYY levels were lower in the WM group (p < 0.05), while fasting and postprandial PYY levels were correlated positively with an increase in body mass index (BMI) in the evaluation (Spearman's rho ≥ 0.395, p < 0.03). Conclusions: Our data do not support the hypothesis that long-term weight regain after bariatric surgery is associated with an unfavourable GI hormone secretion pattern.

Indexed as

gastrointestinal hormonesghrelinGLP-1weight regain

Identifiers

PMID36199737
PMCPMC9528819

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.