Evidence map›Paper›PMID 36199658›Full record

ArticleCureus2022

The Vicious Cycle of Hypothyroidism and Severe Proteinuria: A Case Report.

Shuojohn Li, Mahmoud Alsaiqali, Meenakshi Narayanaswamy, Isabel McFarlane

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Shuojohn LiInternal Medicine, State University of New York Downstate Health Sciences University, Brooklyn, USA.
Mahmoud AlsaiqaliInternal Medicine, State University of New York Downstate Medical Center, Brooklyn, USA.
Meenakshi NarayanaswamyInternal Medicine, State University of New York Downstate Medical Center, Brooklyn, USA.
Isabel McFarlaneInternal Medicine, State University of New York Downstate Medical Center, Brooklyn, USA.
SUNY Downstate Health Sciences University · USState University of New York · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe proteinuria and nephrotic syndrome are well documented causes or exacerbating factor of hypothyroidism. Less commonly known is that hypothyroidism, one of the most commonly encountered endocrinopathies, also has a profound effect on renal function and may lead to proteinuria. Here we report a case of female patient with hypothyroidism who presented with new onset severe proteinuria. Based on clinical data, we suspect the patient may have entered a vicious cycle of hypothyroidism and severe proteinuria where the two conditions worsen each other. Through literature review, we provide summaries of evidence supporting this bidirectional relationship between hypothyroidism and proteinuria, and emphasize on the importance of recognizing such association in clinical practice.

Indexed as

hypothyroidismnephrotic syndromeproteinuriathyroidthyroid supplementvicious cycle

Identifiers

PMID36199658
PMCPMC9526517
OpenAlexW4294098592

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.