Evidence map›Paper›PMID 36199584›Full record

ArticleFrontiers in genetics2022

Systemic lupus erythematosus variants modulate the function of an enhancer upstream of

Satish Pasula, Jaanam Gopalakrishnan, Yao Fu, Kandice L Tessneer, Mandi M Wiley, Richard C Pelikan, Jennifer A Kelly, Patrick M Gaffney

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Frontiers in immunology · 2026
    Article
  3. Review
  4. Article
  5. Aberrant Enhancer Regulation, Phase Separation, and Autoimmune Diseases.Clinical reviews in allergy & immunology · 2025
    Review
  6. Review
  7. Review
  8. Review
  9. International journal of general medicine · 2024
    Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Satish PasulaGenes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.
Jaanam GopalakrishnanGenes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.
Yao FuGenes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.
Kandice L TessneerGenes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.
Mandi M WileyGenes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.
Richard C PelikanGenes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.
Jennifer A KellyGenes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.
Patrick M GaffneyGenes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.
Oklahoma Medical Research Foundation · USUniversity of Oklahoma Health Sciences Center · US

Funding

VALIDATING NOVEL GENES IMPLICATED IN LEUKOCYTE CHEMOTAXISP20RR020143 · NCRR · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI KAUFMAN, KENNETH M · 2004 to 2011
$21.0M
Pre-Clinical Studies to Identify SLE Therapeutic TargetsU19AI082714 · NIAID · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI GAFFNEY, PATRICK M · 2009 to 2018
$6.2M
Quantitative Analysis Core P30GM110766 · NIGMS · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI GAFFNEY, PATRICK M · 2014 to 2018
$6.1M
TNFAIP3 (A20) and Susceptibility to Systemic Lupus ErythematosusR01AR056360 · NIAMS · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI GAFFNEY, PATRICK M · 2009 to 2018
$6.0M
Disease and Race Specific Single-cell Epigenetic Mechanisms in Human SLER01AI156724 · NIAID · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI GAFFNEY, PATRICK M · 2021 to 2025
$4.1M
Oklahoma ACE: Molecular Destruction of Autoimmune Disease to Aid Clinical Trail SuccessUM1AI144292 · NIAID · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI JUDITH A JAMES · 2019 to 2026
$3.3M
Epigenome-Guided Causal Variant Discovery and MechanismsR01AR073606 · NIAMS · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI GAFFNEY, PATRICK M · 2019 to 2023
$3.3M
Functional Mechanisms of Causal Variants in Systemic Lupus ErythematosusR01AR063124 · NIAMS · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI GAFFNEY, PATRICK M · 2012 to 2016
$2.0M
NCRR NIH HHS P20 RR020143NIAID NIH HHS R01 AI156724NIAID NIH HHS U19 AI082714NIAID NIH HHS UM1 AI144292NIAMS NIH HHS R01 AR056360NIAMS NIH HHS R01 AR063124NIAMS NIH HHS R01 AR073606NIGMS NIH HHS P30 GM110766
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

functional geneticsIFNGR1IL20RAsystemic lupus erythematosusTNFAIP3

Identifiers

PMID36199584
PMCPMC9527318
OpenAlexW4296261110

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.