ArticleAmerican journal of preventive cardiology2022
Association between plaque localization in proximal coronary segments and MACE outcomes in patients with mild CAC: Results from the EISNER study.
Article in American journal of preventive cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06029387 (Artificial Intelligence for Preventing Heart Disease), which is not on this map. Cited by 11 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Artificial Intelligence for Preventing Heart Disease: Observational, Single Center, Prospective and Retrospective Study
Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Hidden risk in normal myocardial perfusion scans: AI-detected proximal coronary calcium on CT attenuation maps improves prognosis.European journal of nuclear medicine and molecular imaging · 2026Article
- Coronary artery calcium scoring: expanding the new standard by photon-counting detector CT-Part I: Impact of tube voltage, tube current, slice thickness, and quantum iterative reconstructions.European radiology · 2026Article
- Association of AI-assisted quantitative coronary plaque burden and CT-derived fractional flow reserve with major adverse cardiovascular events.BMC medical imaging · 2026Article
- Distribution, extent, and calculated age of initiation of coronary artery calcification.Polish journal of radiology · 2026Article
- Mitigating Bias in Opportunistic Screening for MACE with Causal Reasoning.IEEE transactions on artificial intelligence · 2025Article
- Automated proximal coronary artery calcium identification using artificial intelligence: advancing cardiovascular risk assessment.European heart journal. Cardiovascular Imaging · 2025Article
- The value of coronary calcium score in predicting clinical outcomes in patients with chronic coronary syndrome.BMC cardiovascular disorders · 2024Article
- Automated segment-level coronary artery calcium scoring on non-contrast CT: a multi-task deep-learning approach.Insights into imaging · 2024Article
- Improved Detection of Small and Low-Density Plaques in Virtual Noncontrast Imaging-based Calcium Scoring at Photon-Counting Detector CT.Radiology. Cardiothoracic imaging · 2024Article
- Impact of Cardiac Motion on coronary artery calcium scoring using a virtual non-iodine algorithm on photon-counting detector CT: a dynamic phantom study.The international journal of cardiovascular imaging · 2023Article
- The site-specific distribution of atheromatous plaques in the coronary arteries.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2023Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Coronary artery calcium score (CAC) is a validated tool to predict and reclassify cardiovascular risk. Additional metrics such as regional distribution and extent of CAC over Agatston CAC score may allow further risk stratification. In this study, we evaluate the prognostic significance of proximal CAC involvement in asymptomatic population from the prospective EISNER (Early-Identification of Subclinical Atherosclerosis by Noninvasive Imaging Research) registry, focusing on patients with mild CAC (score 1-99). Methods: This study included a total of 2,047 adult asymptomatic subject who underwent baseline CAC scan and 14-year follow-up for MACE, defined as myocardial infarction, late revascularization, or cardiac death. Proximal involvement was defined as presence of CAC in the LM, proximal LAD, LCX or RCA. CAC was categorized as 0, 1-99, and ≥100. Results: 1,090 (53.2%) subjects had no CAC, 576 (28.1%) had CAC 1-99, and 381 (18.7%) had CAC ≥100. Proximal involvement was seen in 67.2% of subjects with CAC 1-99 and 97.3% of subjects with CAC ≥100. In the CAC 1-99 category, the presence of proximal CAC was associated with increased MACE risk after adjustment for CAC score, CAC extent and conventional risk factors compared to those without proximal CAC (HR: 2.84 95% CI: 1.29-6.25, p=0.009). Conclusion: In asymptomatic subjects with CAC scores of 1-99, the presence and extent of proximal CAC plaques provides strong independent prognostic information in predicting MACE.
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