Evidence map›Paper›PMID 36199352›Full record

ArticleRSC advances2022

RGD peptide-based lipids for targeted mRNA delivery and gene editing applications.

Jingya Qin, Lulu Xue, Ningqiang Gong, Hanwen Zhang, Sarah J Shepherd, Rebecca M Haley, Kelsey L Swingle, Michael J Mitchell

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
  2. Article
  3. Secondary Site Ligand for Integrin αVβ3 Enables Targeted mRNA Delivery.Angewandte Chemie (International ed. in English) · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Formulation methods for peptide-modified lipid nanoparticles.Journal of controlled release : official journal of the Controlled Release Society · 2025
    Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Precision treatment of viral pneumonia through macrophage-targeted lipid nanoparticle delivery.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jingya QinDepartment of Bioengineering, University of Pennsylvania Philadelphia PA 19104 USA mjmitch@seas.upenn.edu.
Lulu XueDepartment of Bioengineering, University of Pennsylvania Philadelphia PA 19104 USA mjmitch@seas.upenn.edu.ORCID https://orcid.org/0000-0001-5719-1336
Ningqiang GongDepartment of Bioengineering, University of Pennsylvania Philadelphia PA 19104 USA mjmitch@seas.upenn.edu.
Hanwen ZhangDepartment of Bioengineering, University of Pennsylvania Philadelphia PA 19104 USA mjmitch@seas.upenn.edu.
Sarah J ShepherdDepartment of Bioengineering, University of Pennsylvania Philadelphia PA 19104 USA mjmitch@seas.upenn.edu.
Rebecca M HaleyDepartment of Bioengineering, University of Pennsylvania Philadelphia PA 19104 USA mjmitch@seas.upenn.edu.ORCID https://orcid.org/0000-0001-7322-7829
Kelsey L SwingleDepartment of Bioengineering, University of Pennsylvania Philadelphia PA 19104 USA mjmitch@seas.upenn.edu.ORCID https://orcid.org/0000-0001-8475-9206
Michael J MitchellDepartment of Bioengineering, University of Pennsylvania Philadelphia PA 19104 USA mjmitch@seas.upenn.edu.ORCID https://orcid.org/0000-0002-3628-2244
University of Pennsylvania · USCalifornia Institute for Regenerative Medicine · US

Funding

In utero gene editing to cure a metabolic liver diseaseR01DK123049 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI PERANTEAU, WILLIAM H. · 2020 to 2024
$3.7M
Targeting stem-like cells and their niche in pancreatic cancerR37CA244911 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Tuomas Tammela · 2020 to 2026
$3.4M
A data-driven drug delivery (4D) platform for probing and treating the chemoresistant bone marrow microenvironmentDP2TR002776 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI MITCHELL, MICHAEL J · 2018 to 2018
$2.4M
Modular approach for the delivery of antibodies into the cytoplasm of cellsR01CA241661 · NCI · UNIVERSITY OF PENNSYLVANIA · PI TSOURKAS, ANDREW · 2019 to 2023
$1.8M
NCATS NIH HHS DP2 TR002776NCI NIH HHS R01 CA241661NCI NIH HHS R37 CA244911NIDDK NIH HHS R01 DK123049
6 · The paper itself

Abstract

mRNA therapeutics are promising platforms for protein replacement therapies and gene editing technologies. When delivered

Identifiers

PMID36199352
PMCPMC9450108
OpenAlexW4297676565

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.