ArticleBrain and behavior2022
Targeting microglial NLRP3 in the SNc region as a promising disease-modifying therapy for Parkinson's disease.
Article in Brain and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Atmospheric Aerosol Neurotoxicity and Parkinson's Disease: Mechanisms and Perspectives.Journal of biochemical and molecular toxicology · 2026Review
- Interplay Between Aging and Glial Cell Dysfunction: Implications for CNS Health.Life (Basel, Switzerland) · 2025Review
- Semaglutide and adenosine alleviate obesity-induced kidney injury, with observed modulation of the Txnip/NLRP3 pathway.Diabetology & metabolic syndrome · 2025Article
- Targeting microglial NLRP3 in the SNc region as a promising disease-modifying therapy for Parkinson's disease.Brain and behavior · 2022Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
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Abstract
introductionParkinson's disease (PD) is a neurodegenerative disorder characterized by progressive loss of dopaminergic (DA) neurons. Accumulating evidence has shown that activation of the NLR family pyrin domain-containing 3 (NLRP3) inflammasome is an early and cardinal feature in PD progression. Nevertheless, little is known about the effect of NLRP3 in the substantia nigra pars compacta (SNc) on DA neurodegeneration. METHODS AND
resultsIn the present study, we constructed NLRP3 interference sequences wrapped by lentivirus (LV3-siNlrp3) to facilitate NLRP3 knockdown in the SNc region by intracerebral stereotactic injection. Then, we explored the effects of NLPR3 knockdown on PD pathologies via behavioral monitoring, immunohistochemistry and western blot analysis in acute 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) mouse model. Moreover, we performed in vitro experiments to investigate the effect of microglial NLRP3 knockdown on DA neuron survival in the context of 1-methyl-4-phenylpyridinium (MPP
conclusionsThis work demonstrates the role of NLRP3 in PD pathogenesis via microglia-neuron communication, and sheds light on targeting microglial NLRP3 to develop disease-modifying therapy for PD.
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