ArticleAngewandte Chemie (International ed. in English)2022
Biosynthesis of Nodulisporic Acids: A Multifunctional Monooxygenase Delivers a Complex and Highly Branched Array.
Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Genome mining guided identification of new furo[3,2-c]pyridones phaeopyridones A-C from the endophytic fungus Phaeobotryon negundinis 12020.Natural products and bioprospecting · 2026Article
- Synthetic Biology in Natural Product Biosynthesis.Chemical reviews · 2025Review
- Biochemistry and Chemoinformatics Guided Classification of Hirsutane Sesquiterpenes Isolated from Mushroom.JACS Au · 2025Article
- Biosynthetic Strategies of Berberine Bridge Enzyme-like Flavoprotein Oxidases toward Structural Diversification in Natural Product Biosynthesis.Biochemistry · 2024Review
- Biochemical characterization of a multiple prenyltransferase from Tolypocladium inflatum.Applied microbiology and biotechnology · 2024Article
- Functional Crosstalk between Discrete Indole Terpenoid Gene Clusters inOrganic letters · 2023Article
- Sustainable metabolic engineering requires a perfect trifecta.Current opinion in biotechnology · 2023Review
- Generation of Alternate Indole Diterpene Architectures in Two Species ofJournal of the American Chemical Society · 2023Article
- Biosynthesis of Nodulisporic Acids: A Multifunctional Monooxygenase Delivers a Complex and Highly Branched Array.Angewandte Chemie (International ed. in English) · 2022Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nodulisporic acids (NAs) are structurally complex potent antiinsectan indole diterpenes. We previously reported the biosynthetic gene cluster for these metabolites in Hypoxylon pulicicidum and functionally characterised the first five steps of the biosynthetic pathway. Here we reveal a highly complex biosynthetic array, furnishing multiple end products through expression of cluster components in Penicillium paxilli. We show that seven additional cluster-encoded gene products comprise the biosynthetic machinery that elaborate precursor NAF in this highly branched pathway. The combined action of these enzymes delivers 37 NA congeners including four major end products, NAA, NAA
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