ArticleAging cell2022
SIRT3 deficiency decreases oxidative metabolism capacity but increases lifespan in male mice under caloric restriction.
Open access · goldAbstract read
In one paragraph
Article in Aging cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Rapamycin, Not Metformin, Mirrors Dietary Restriction-Driven Lifespan Extension in Vertebrates: A Meta-Analysis.Aging cell · 2025Pooled it
- Loss of sirtuin 3 disrupts cellular senescence signaling pathways.GeroScience · 2026Article
- Reducing the strain on calorie restriction.Life metabolism · 2026Article
- Biomarkers of Cardiac Metabolic Flexibility in Health, HFrEF and HFpEF.International journal of molecular sciences · 2026Review
- Trajectories of cardiovascular ageing-from molecular mechanisms to clinical implementation.Cardiovascular research · 2025Review
- Nutrition and Aging Biology: Summary of a Research Centers Collaborative Network Workshop and Research Needs.Current developments in nutrition · 2025Article
- Review
- Exploring New Ways to Analyze Data on the Spontaneous Physical Activity of Rodents Through a Weighing Balance.Sensors (Basel, Switzerland) · 2025Article
- Resveratrol and Physical Activity: A Successful Combination for the Maintenance of Health and Wellbeing?Nutrients · 2025Review
- Role of AMPK and Sirtuins in Aging Heart: Basic and Translational Aspects.Aging and disease · 2024Review
- Review
- A nutrigeroscience approach: Dietary macronutrients and cellular senescence.Cell metabolism · 2024Review
- The Roles of White Adipose Tissue and Liver NADPH in Dietary Restriction-Induced Longevity.Antioxidants (Basel, Switzerland) · 2024Review
- Critical Velocity, Maximal Lactate Steady State, and Muscle MCT1 and MCT4 after Exhaustive Running in Mice.International journal of molecular sciences · 2023Article
- Combinatorial interventions in aging.Nature aging · 2023Review
- Challenges in anti-aging medicine-trends in biomarker discovery and therapeutic interventions for a healthy lifespan.Journal of cellular and molecular medicine · 2023Review
- Vascular Ageing: Mechanisms, Risk Factors, and Treatment Strategies.International journal of molecular sciences · 2023Review
- SIRT3 deficiency decreases oxidative metabolism capacity but increases lifespan in male mice under caloric restriction.Aging cell · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 2 countries.
Rashpal S DhillonDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Yiming Amy QinDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID https://orcid.org/0000-0002-2413-0024
Paul R van GinkelDepartment of Genetics and Medical Genetics, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Vivian X FuDepartment of Genetics and Medical Genetics, University of Wisconsin-Madison, Madison, Wisconsin, USA.
James M VannDepartment of Genetics and Medical Genetics, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Alexis J LawtonDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Cara L GreenDepartment of Medicine, SMPH, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Fúlvia B Manchado-GobattoLaboratory of Applied Sport Physiology, School of Applied Sciences, University of Campinas, Limeira, Brazil.
Claudio A GobattoLaboratory of Applied Sport Physiology, School of Applied Sciences, University of Campinas, Limeira, Brazil.
Dudley W LammingInterdepartmental Graduate Program in Nutritional Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Tomas A ProllaDepartment of Genetics and Medical Genetics, University of Wisconsin-Madison, Madison, Wisconsin, USA.
John M DenuDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
University of Wisconsin–Madison · USUniversidade Estadual de Campinas (UNICAMP) · BR
Funding
Reversible protein acetylation and sirtuin functionR01GM065386 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI DENU, JOHN M · 2003 to 2022
$7.3MThe regulation of health and longevity by branched-chain amino acidsR01AG056771 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Dudley William Lamming · 2018 to 2026
$3.1MThe regulation of health and longevity by branched-chain amino acidsRF1AG056771 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI LAMMING, DUDLEY WILLIAM · 2023 to 2023
$2.1MComparative analysis of geroprotective interventions in established and novel mouse models of Alzheimer's diseaseR01AG062328 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI LAMMING, DUDLEY WILLIAM, MERRINS, MATTHEW J. · 2018 to 2022
$2.0MDietary regulation of the hepatic epigenomeR01DK125859 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI DENU, JOHN M, LAMMING, DUDLEY WILLIAM · 2021 to 2023
$1.8MRole of Sirt3 in Aging and Caloric RestrictionR01AG038679 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI DENU, JOHN M, PROLLA, TOMAS ALBERTO · 2011 to 2016
$1.6MThe regulation of health and longevity by branched-chain amino acidsR56AG056771 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI LAMMING, DUDLEY WILLIAM · 2017 to 2017
$573kTranslation analysis of a novel intervention for diet-induced obesityR21AG061635 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI COLMAN, RICKI J, LAMMING, DUDLEY WILLIAM · 2019 to 2020
$426kPromoting metabolic health through the reduction of dietary branched chain amino acidsI01BX004031 · VA · WM S. MIDDLETON MEMORIAL VETERANS HOSP · PI LAMMING, DUDLEY WILLIAM · 2018 to 2022
–BLRD VA I01 BX004031NIA NIH HHS AG038679NIA NIH HHS AG056771NIA NIH HHS AG061635NIA NIH HHS AG062328NIA NIH HHS GM65386NIA NIH HHS R01 AG038679NIA NIH HHS R01 AG056771NIA NIH HHS R01 AG062328NIDDK NIH HHS DK125859NIDDK NIH HHS R01 DK125859NIGMS NIH HHS R01 GM065386
Abstract
Mitochondrial NAD
Indexed as
Caloric RestrictionLongevitySirtuin 3AcetylationAgingAnimalsMaleMiceMitochondriaOxidative StressSirt3 protein, mouseSirtuin 3aerobic fitnesscalorie restrictionfatty acid oxidationfuel switchinglifespanmitochondrial acetylationmitochondrial respirationsirtuins
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.