ArticleBMC pulmonary medicine2022
Prognostic value of lymphocyte count for in-hospital mortality in patients with severe AECOPD.
Article in BMC pulmonary medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 16 citations in OpenAlex.
- Development and Validation of a Predictive Nomogram for Progression from Pre-COPD to Spirometric COPD: A Multicenter Retrospective Cohort Study.International journal of chronic obstructive pulmonary disease · 2026Article
- Explainable machine learning model for 1-year readmission risk prediction in AECOPD patients: integrating relief feature selection with sample augmentation.BMC infectious diseases · 2025Article
- Serum electrolytes as prognostic markers: a new frontier in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) management.Journal of thoracic disease · 2025Article
- Development and validation of a machine learning-based model to predict the risk of hospitalization death in hospitalized patients with AECOPD.Scientific reports · 2025Article
- Unraveling the Immune Landscape of Chronic Obstructive Pulmonary Disease: Insights into Inflammatory Cell Subtypes, Pathogenesis, and Treatment Strategies.International journal of molecular sciences · 2025Review
- Correlation between controlling nutritional status score and mortality risk in older Japanese adults diagnosed with dysphagia: a retrospective cohort study.Frontiers in nutrition · 2025Article
- Inflammatory markers as predictors of in-hospital mortality in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients with acute respiratory failure: insights from the MIMIC-IV database.Journal of thoracic disease · 2024Article
- Clinical relevance of blood urea nitrogen to serum albumin ratio for predicting bacteremia in very young children with febrile urinary tract infection.Kidney research and clinical practice · 2024Article
- A predictive model for frequent exacerbator phenotype of acute exacerbations of chronic obstructive pulmonary disease.Journal of thoracic disease · 2023Article
- Using complete blood count, serum immunoglobulins G/A/M and complement C3/C4 levels to predict the risk of COPD acute exacerbation: 2-year follow-up in a single-center prospective cohort study.Clinical and experimental medicine · 2023Observational
- Serum YKL-40 Levels, Leukocyte Profiles, and Acute Exacerbations of Advanced COPD.Journal of clinical medicine · 2023Article
- Article
- Association between the prognostic nutritional index (PNI) and all-cause mortality in patients with chronic kidney disease.Renal failure · 2023Article
- Patients' outcomes during chronic obstructive pulmonary disease exacerbations are associated with the severity score of the Lancet Commission.Annals of thoracic medicineArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPatients with severe acute exacerbations of chronic obstructive pulmonary disease often have a poor prognosis. Biomarkers can help clinicians personalize the assessment of different patients and mitigate mortality. The present study sought to determine if the lymphocyte count could act as a risk factor for mortality in individuals with severe AECOPD.
methodsA retrospective study was carried out with 458 cases who had severe AECOPD. For analysis, patients were divided into two groups on the basis of lymphocyte count: < 0.8 × 10
resultsPatients who fulfilled the criteria for inclusion were enrolled, namely 458 with a mean age of 78.2 ± 8.2 years. Of these patients, 175 had a low lymphocyte count. Compared to patients with normal lymphocyte counts, those with low counts were older (79.2 ± 7.4 vs. 77.5 ± 8.6 years, p = 0.036), had lower activities of daily living scores on admission (35.9 ± 27.6 vs. 47.5 ± 17.1, p < 0.001), and had a greater need for home oxygen therapy (84.6 vs. 72.1%, p = 0.002). Patients with low lymphocytes had higher mortality rates during hospitalization (17.1 vs. 7.1%, p = 0.001), longer hospital stay (median [IQR] 16 days [12-26] vs. 14 days [10-20], p = 0.002) and longer time on mechanical ventilation (median [IQR] 11.6 days [5.8-18.7] vs. 10.9 days [3.8-11.6], p < 0.001). The logistic regression analysis showed lymphocyte count < 0.8 × 10
conclusionLymphocyte count could act as a predictor of mortality in patients with severe AECOPD.
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