Evidence map›Paper›PMID 36199130›Full record

ArticleBMC cancer2022

Adjuvant effect of IRES-based single-stranded RNA on melanoma immunotherapy.

Hye Won Kwak, So-Hee Hong, Hyo-Jung Park, Hyeong-Jun Park, Yoo-Jin Bang, Jae-Yong Kim, Yu-Sun Lee, Seo-Hyeon Bae, Hyunho Yoon, Jae-Hwan Nam

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Hye Won KwakDepartment of Medical and Biological Sciences, The Catholic University of Korea, 43-1 Yeokgok-dong, Wonmi-gu, Bucheon, 14662, Republic of Korea.
So-Hee HongDepartment of Microbiology, College of Medicine, Ewha Womans University, Seoul, 07804, Republic of Korea.
Hyo-Jung ParkDepartment of Medical and Biological Sciences, The Catholic University of Korea, 43-1 Yeokgok-dong, Wonmi-gu, Bucheon, 14662, Republic of Korea.
Hyeong-Jun ParkDepartment of Medical and Biological Sciences, The Catholic University of Korea, 43-1 Yeokgok-dong, Wonmi-gu, Bucheon, 14662, Republic of Korea.
Yoo-Jin BangDepartment of Medical and Biological Sciences, The Catholic University of Korea, 43-1 Yeokgok-dong, Wonmi-gu, Bucheon, 14662, Republic of Korea.
Jae-Yong KimDepartment of Medical and Biological Sciences, The Catholic University of Korea, 43-1 Yeokgok-dong, Wonmi-gu, Bucheon, 14662, Republic of Korea.
Yu-Sun LeeDepartment of Medical and Biological Sciences, The Catholic University of Korea, 43-1 Yeokgok-dong, Wonmi-gu, Bucheon, 14662, Republic of Korea.
Seo-Hyeon BaeDepartment of Medical and Biological Sciences, The Catholic University of Korea, 43-1 Yeokgok-dong, Wonmi-gu, Bucheon, 14662, Republic of Korea.
Hyunho YoonDepartment of Medical and Biological Sciences, The Catholic University of Korea, 43-1 Yeokgok-dong, Wonmi-gu, Bucheon, 14662, Republic of Korea. hyoon@catholic.ac.kr.
Jae-Hwan NamDepartment of Medical and Biological Sciences, The Catholic University of Korea, 43-1 Yeokgok-dong, Wonmi-gu, Bucheon, 14662, Republic of Korea. jhnam@catholic.ac.kr.
Catholic University of Korea · KREwha Womans University · KR

Funding

the Ministry of Food and Drug Safety 22213MFDS421the National Research Foundation of Korea NRF-2021M3E5E3080588the Research Unit of Korea Center for Disease Control and Prevention 2020-ER5303-02
6 · The paper itself

Abstract

backgroundAdjuvant therapies such as radiation therapy, chemotherapy, and immunotherapy are usually given after cancer surgery to improve the survival of cancer patients. However, despite advances in several adjuvant therapies, they are still limited in the prevention of recurrences.

methodsWe evaluated the immunological effects of RNA-based adjuvants in a murine melanoma model. Single-stranded RNA (ssRNA) were constructed based on the cricket paralysis virus (CrPV) internal ribosome entry site (IRES). Populations of immune cells in bone marrow cells and lymph node cells following immunization with CrPV

resultsCrPV

conclusionsThis study provides evidence that the CrPV

Indexed as

Cancer VaccinesMelanomaAdjuvants, ImmunologicAnimalsImmunotherapyInterferon-gammaInternal Ribosome Entry SitesMiceRNA, ViralAdjuvants, ImmunologicCancer VaccinesInterferon-gammaInternal Ribosome Entry SitesRNA, ViralAdjuvant immunotherapyAntigen-presenting cellsCrPVIRES-ssRNAMurine melanoma modelRNA vaccine

Identifiers

PMID36199130
PMCPMC9533600
OpenAlexW4301393897

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.