ArticleAlzheimer's research & therapy2022
Associations of resting heart rate with incident dementia, cognition, and brain structure: a prospective cohort study of UK biobank.
Article in Alzheimer's research & therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Linking cortical structure and delirium in the elderly: insights from cohort study and shared genetic risk analysis.Journal of translational medicine · 2026Article
- Nonlinear L-shaped association between composite dietary antioxidant index and risk of dementia: a prospective cohort study.Frontiers in public health · 2026Article
- Minimum pulse rate during sleep as a MMSE-associated factor: a multifaceted exploratory study in older adults without long-term care certification.BMC geriatrics · 2025Article
- Relationship between minimum heart rate and mortality in ICU patients with traumatic brain injury (TBI): a retrospective analysis based on the MIMIC-IV database.Surgery in practice and science · 2025Article
- Heart rate response and recovery during exercise and dementia risk: a prospective UK biobank study.Scientific reports · 2025Article
- Enhancing the validity of CAIDE dementia risk scores with resting heart rate and machine learning: An analysis from the National Alzheimer's Coordinating Center across all races/ethnicities.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Molecular Marker Discovery and Evaluation: EGF rs1897990 and rs1524106 Variants in a China Lung Adenocarcinoma Young Population.The clinical respiratory journal · 2025Article
- Moderate tea consumption and dementia-related neuroimaging markers.Frontiers in neurology · 2025Article
- Osteoarthritis, osteoarthritis treatment and risk of incident dementia: a prospective cohort study based on UK Biobank.Age and ageing · 2024Article
- Associations of computer gaming with incident dementia, cognitive functions, and brain structure: a prospective cohort study and Mendelian randomization analysis.Alzheimer's research & therapy · 2024Article
- Resting heart rate causally affects the brain cortical structure: Mendelian randomization study.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Association between Resting Heart Rate and Machine Learning-Based Brain Age in Middle- and Older-Age.The journal of prevention of Alzheimer's disease · 2024Article
- Article
- Systemic Inflammatory Response Index (SIRI) is associated with all-cause mortality and cardiovascular mortality in population with chronic kidney disease: evidence from NHANES (2001-2018).Frontiers in immunology · 2024Article
- Resting heart rate, cognitive function, and inflammation in older adults: a population-based study.Aging clinical and experimental research · 2023Article
- Ranking the risk factors for Alzheimer's disease; findings from the UK Biobank study.Aging brain · 2023Article
- A lightweight machine learning tool for Alzheimer's disease prediction.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Heart Rate and its Variability From Short-Term ECG Recordings as Potential Biomarkers for Detecting Mild Cognitive Impairment.American journal of Alzheimer's disease and other dementiasArticle
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15 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundResting heart rate (RHR) has been linked with an increased risk of dementia. However, evidence characterizing the associations of RHR with different dementia subtypes and their underlying mechanisms remains scarce. This study aims to investigate the relationships of RHR with different dementia types, cognitive function, and brain structural abnormalities.
methodsThree hundred thirty-nine thousand nine hundred one participants with no prior diagnosis of dementia from the UK biobank were analyzed. Cox regression and restricted cubic spline models examined the associations between RHR with all-cause dementia (ACD) and its major subtypes-Alzheimer's disease (AD) and vascular dementia (VaD). Logistic regression models assessed the associations of RHR with cognitive function, and linear regression models estimated the associations with hippocampal subfield volume and white matter tract integrity indexed by magnetic resonance imaging data.
resultsDuring an average of 3148 (± 941.08) days of follow-up, 4177 individuals were diagnosed with dementia, including 2354 AD and 989 VaD cases. RHR ≥ 80bpm was associated with ACD (HR: 1.18, 95% CI: 1.08-1.28, P < 0.001) and VaD (HR: 1.29, 95% CI: 1.08-1.54, P = 0.005) but not AD in multi-adjusted models. A 10-bpm increment of RHR demonstrated non-linear effects in VaD, consisting of J-shape relationships. Several heterogeneities were indicated in stratified analysis, in which RHR measures only showed associations with dementia incidents in relatively younger populations (age ≤ 65) and females. Apart from dementia analysis, elevated RHR was associated with worsening performance in fluid intelligence and reaction time of cognitive tasks, decreased hippocampal subfields volume, and poor white matter tract integrity.
conclusionsRHR is associated with increased risks of ACD and VaD but also presented with few heterogeneities across different sex and age groups. Elevated RHR also appears to have deleterious effects on cognitive function and is distinctively associated with volume reduction in hippocampal subfields and impaired white matter tract integrity.
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