Evidence map›Paper›PMID 36199097›Full record

ArticleJournal of neuroinflammation2022

Microglial-oligodendrocyte interactions in myelination and neurological function recovery after traumatic brain injury.

Shanshan Song, Md Nabiul Hasan, Lauren Yu, Satya S Paruchuri, John P Bielanin, Shamseldin Metwally, Helena C M Oft, Sydney G Fischer, Victoria M Fiesler, Tanusree Sen and 7 more

Open access · goldAbstract read
In one paragraph

Article in Journal of neuroinflammation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
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  6. Revisiting the critical roles of reactive microglia in traumatic brain injury.International journal of surgery (London, England) · 2025
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  16. Recombinant Erythropoietin Induces Oligodendrocyte Progenitor Cell Proliferation After Traumatic Brain Injury and Delayed Hypoxemia.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 1 country.

Shanshan Song *Department of Neurology, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA, 15213, USA.
Md Nabiul Hasan *Department of Neurology, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA, 15213, USA.
Lauren YuDepartment of Neurology, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA, 15213, USA.
Satya S ParuchuriDepartment of Neurology, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA, 15213, USA.
John P BielaninDepartment of Neurology, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA, 15213, USA.
Shamseldin MetwallyDepartment of Neurology, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA, 15213, USA.
Helena C M OftDepartment of Neurology, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA, 15213, USA.
Sydney G FischerDepartment of Neurology, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA, 15213, USA.
Victoria M FieslerDepartment of Neurology, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA, 15213, USA.
Tanusree SenDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Rajaneesh K GuptaDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Lesley M FoleyAnimal Imaging Center, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
T Kevin HitchensAnimal Imaging Center, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
C Edward DixonVeterans Affairs Pittsburgh Health Care System, Pittsburgh, PA, 15213, USA.
Franca CambiDepartment of Neurology, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA, 15213, USA.
Nilkantha SenDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Dandan SunDepartment of Neurology, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA, 15213, USA. sund@upmc.edu.
Institute for Neurodegenerative Disorders · USUniversity of Pittsburgh · USImaging Center · USNeurological Surgery · USVA Pittsburgh Healthcare System · US

Funding

TRAINING PROGRAM FOR MD/PHD STUDENTST32GM008208 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STEINMAN, RICHARD A · 1987 to 2021
$15.4M
Microglia in White Matter Repair after TBII01BX004625 · VA · VETERANS HEALTH ADMINISTRATION · PI SUN, DANDAN · 2020 to 2024
–
BLRD Research Career Scientist Award ApplicationIK6BX005647 · VA · VETERANS HEALTH ADMINISTRATION · PI Dandan Sun · 2021 to 2026
–
BLRD VA I01 BX004625BLRD VA IK6 BX005647NIGMS NIH HHS T32 GM008208U.S. Department of Veterans Affairs I01BX004625
6 · The paper itself

Abstract

Differential microglial inflammatory responses play a role in regulation of differentiation and maturation of oligodendrocytes (OLs) in brain white matter. How microglia-OL crosstalk is altered by traumatic brain injury (TBI) and its impact on axonal myelination and neurological function impairment remain poorly understood. In this study, we investigated roles of a Na

Indexed as

Brain Injuries, TraumaticWhite MatterAnimalsDisease Models, AnimalMiceMice, Inbred C57BLMicrogliaOligodendrogliaRecovery of FunctionInflammationMicrogliaNa+/H+ exchangerOligodendrocytesTraumatic brain injuryWhite matter damage

Identifiers

PMID36199097
PMCPMC9533529
OpenAlexW4301600570

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.