Observational studyCritical care (London, England)2022
Doppler study of portal vein and renal venous velocity predict the appropriate fluid response to diuretic in ICU: a prospective observational echocardiographic evaluation.
Observational study in Critical care (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07291778 (The Impact of VeXUS-guided Fluid Management in ICU Populations on Renal Function), which is not on this map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Impact of VeXUS-guided Fluid Management in ICU Populations on Renal Function
Who cites it
29 citing papers in PubMed, 48 citations in OpenAlex.
- Portal Vein Doppler Parameters as Indicators of Volume Status in Hemodialysis Patients Using Wireless Ultrasound.Cureus · 2026Article
- Rethinking Congestion in Heart Failure from Volume Overload to Venous Pressure and Organ Disfunction with VExUS.Medicina (Kaunas, Lithuania) · 2026Review
- Positioning Statement on the Use of Point-of-Care Ultrasound in Cardiovascular Medicine - 2026.Arquivos brasileiros de cardiologia · 2026Article
- Feasibility and early experience with venous Doppler congestion assessment in post-operative lung transplant patients.The ultrasound journal · 2026Article
- Feasibility, reproducibility, clinical value of the VExUS score after pediatric cardiac surgery and main differences from adults' perspective.European journal of pediatrics · 2026Observational
- VExUS versus CVP for assessing venous congestion: oasis or mirage?Critical care (London, England) · 2026Article
- Modified Venous Excess Ultrasound (mVExUS) in the Prediction of Ventilator Weaning Failure: a Cohort Study.POCUS journal · 2026Article
- Association between VExUS score and worsening renal function during diuretic therapy in the ICU.Intensive care medicine experimental · 2026Article
- Assessment of Congestion in Heart Failure Using VExUS: Current Evidence, Limitations and Clinical Perspectives.Life (Basel, Switzerland) · 2026Review
- Lung and Venous Excess Ultrasound Correlation With Intracardiac Pressures Before and After Decongestion in Critically Ill Patients With Acute Decompensated Heart Failure.Critical care explorations · 2026Observational
- A comprehensive review of venous excess ultrasound (VExUS) score: evidence from original research.Internal and emergency medicine · 2026Review
- VExUS score: optimizing its use in perioperative and critical care management.Critical care (London, England) · 2025Review
- Changes in hepatic and renal Doppler ultrasonography: Current standard therapy in dogs with congestive heart failure.Open veterinary journal · 2025Article
- Renal perfusion pressure: role and implications in critical illness.Annals of intensive care · 2025Review
- Decoding portal vein pulsatility: hemodynamic determinants in a post-hoc analysis of a prospective observational trial.Annals of intensive care · 2025Article
- Venous excess ultrasound score association with acute kidney injury in critically ill patients: a systematic review and meta-analysis of observational studies.The ultrasound journal · 2025Review
- Point-of-Care Ultrasonography in the Critical Care Unit: An Update.Current cardiology reports · 2025Review
- Contemporary clinical applications of venous excess ultrasound: A scoping review protocol.PloS one · 2025Article
- Changes in portal pulsatility index induced by a fluid challenge in patients with haemodynamic instability and systemic venous congestion: a prospective cohort study.Annals of intensive care · 2024Article
- Venous Excess Ultrasound for Fluid Assessment in Complex Cardiac Patients With Acute Kidney Injury.Cureus · 2024Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFluid overload and venous congestion are associated with morbi-mortality in the ICU (intensive care unit). Administration of diuretics to correct the fluid balance is common, although there is no strong relationship between the consequent fluid loss and clinical improvement. The aim of the study was to evaluate the ability of the portal pulsatility index, the renal venous impedance index, and the VEXUS score (venous ultrasound congestion score) to predict appropriate diuretic-induced fluid depletion.
methodsThe study had a prospective, observational, single-center observational design and was conducted in a university-affiliated medico-surgical ICU. Adult patients for whom the clinician decided to introduce loop diuretic treatment were included. Hemodynamic and ultrasound measurements (including the portal pulsatility index, renal venous impedance index and VEXUS score) were performed at inclusion and 2 hours after the initiation of the diuretics. The patients' characteristics were noted at inclusion, 24 h later, and at ICU discharge. The appropriate diuretic-induced fluid depletion was defined by a congestive score lower than 3 after diuretic fluid depletion. The congestive score included clinical and biological parameters of congestion.
resultsEighty-one patients were included, and 43 (53%) patients presented with clinically significant congestion score at inclusion. Thirty-four patients (42%) had an appropriate response to diuretic-induced fluid depletion. None of the left- and right-sided echocardiographic parameters differed between the two groups. The baseline portal pulsatility index was the best predictor of appropriate response to diuretic-induced fluid depletion (AUC = 0.80, CI
conclusionThe portal pulsatility index and the renal venous impedance index were predictive of the appropriate response to diuretic-induced fluid depletion in ICU patients. The portal pulsatility index should be evaluated in future randomized studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.