Evidence map›Paper›PMID 36198876›Full record

ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2023

Assessing the mechanisms of brain plasticity by transcranial magnetic stimulation.

Ali Jannati, Lindsay M Oberman, Alexander Rotenberg, Alvaro Pascual-Leone

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06069323 (Therapeutic Use of Repetitive Transcranial Magnetic Stimulation), which is not on this map. Cited by 157 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
157citing papers in PubMed, 15 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06069323 naunknown statusnot on this map

Therapeutic Use of Repetitive Transcranial Magnetic Stimulation (rTMS) in Pediatric Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Cohorts (ADHD): a Randomized, Sham-controlled Study.

TypeinterventionalSponsorOspedali Riuniti di FoggiaRan2023 to 2026Enrolled80ConditionsAutism Spectrum Disorder, ADHD, Neurodevelopmental DisordersArmsrepetitive Transcranial Magnetic Stimulation
3 · Its place in the literature

Who cites it

157 citing papers in PubMed, 15 syntheses or guidelines pooled it.

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  6. Comparison of therapeutic efficacy in depression between repetitive TMS and deep TMS.Journal of neural transmission (Vienna, Austria : 1996) · 2025
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  11. Intervention modalities for brain fog caused by long-COVID: systematic review of the literature.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
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97 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ali JannatiNeuromodulation Program, Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. ali.jannati@childrens.harvard.edu.ORCID http://orcid.org/0000-0003-0826-1275
Lindsay M ObermanCenter for Neuroscience and Regenerative Medicine, Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Alexander RotenbergNeuromodulation Program, Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Alvaro Pascual-LeoneDepartment of Neurology, Harvard Medical School, Boston, MA, USA. apleone@hsl.harvard.edu.

Funding

Non-invasive Neuromodulation Unit (NNU)ZIAMH002955 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI ZARATE, CARLOS · 2016 to 2025
$40.3M
The Role of Inflammation in the Pathophysiology of Delirium and its Associated Long-Term Cognitive DeclineP01AG031720 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI SHAFI, MOUHSIN · 2010 to 2022
$26.7M
Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4M
Collaboratory on Research Definitions for Cognitive Reserve and ResilienceR24AG061421 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI STERN, YAAKOV · 2018 to 2020
$2.5M
Cortical Plasticity in Autism Spectrum DisordersR01MH100186 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ROTENBERG, ALEXANDER · 2014 to 2018
$2.2M
Mapping progressive loss of intracortical inhibition by TMS and EEG in posttraumatic epileptogenesisR01NS088583 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI ROTENBERG, ALEXANDER · 2015 to 2019
$1.9M
NIA NIH HHS P01 AG031720NIA NIH HHS R24 AG061421NICHD NIH HHS P50 HD105351NIMH NIH HHS R01 MH100186NINDS NIH HHS R01 NS088583
6 · The paper itself

Abstract

Transcranial magnetic stimulation (TMS) is a non-invasive technique for focal brain stimulation based on electromagnetic induction where a fluctuating magnetic field induces a small intracranial electric current in the brain. For more than 35 years, TMS has shown promise in the diagnosis and treatment of neurological and psychiatric disorders in adults. In this review, we provide a brief introduction to the TMS technique with a focus on repetitive TMS (rTMS) protocols, particularly theta-burst stimulation (TBS), and relevant rTMS-derived metrics of brain plasticity. We then discuss the TMS-EEG technique, the use of neuronavigation in TMS, the neural substrate of TBS measures of plasticity, the inter- and intraindividual variability of those measures, effects of age and genetic factors on TBS aftereffects, and then summarize alterations of TMS-TBS measures of plasticity in major neurological and psychiatric disorders including autism spectrum disorder, schizophrenia, depression, traumatic brain injury, Alzheimer's disease, and diabetes. Finally, we discuss the translational studies of TMS-TBS measures of plasticity and their therapeutic implications.

Indexed as

Autism Spectrum DisorderTranscranial Magnetic StimulationAdultBrainHumansNeuronal Plasticity

Identifiers

PMID36198876
PMCPMC9700722

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.