Evidence map›Paper›PMID 36198803›Full record

ArticleNature2022

Programmable RNA sensing for cell monitoring and manipulation.

Yongjun Qian, Jiayun Li, Shengli Zhao, Elizabeth A Matthews, Michael Adoff, Weixin Zhong, Xu An, Michele Yeo, Christine Park, Xiaolu Yang and 3 more

Open access · greenAbstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 1 pooled it
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 1 synthesis or guideline pooled it, 122 citations in OpenAlex.

  1. Engineering CRISPR guide RNAs for programmable RNA sensors.Biochemical Society transactions · 2023
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Evolution of Engineered ADAR-Based RNA Editing Systems.International journal of molecular sciences · 2026
    Review
  14. Article
  15. Article
  16. Article
  17. Protein engineering: status report.Protein engineering, design & selection : PEDS · 2026
    Review
  18. Article
  19. Review
  20. Genetic Tools in Rodents to Study Cannabinoid Functions.Current topics in behavioral neurosciences · 2026
    Review

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Yongjun QianDepartment of Neurobiology, Duke University Medical Center, Durham, NC, USA.
Jiayun LiCold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY, USA.
Shengli ZhaoDepartment of Neurobiology, Duke University Medical Center, Durham, NC, USA.
Elizabeth A MatthewsDepartment of Neurobiology, Duke University Medical Center, Durham, NC, USA.
Michael AdoffDepartment of Neurobiology, Duke University Medical Center, Durham, NC, USA.
Weixin ZhongDepartment of Neurobiology, Duke University Medical Center, Durham, NC, USA.
Xu AnDepartment of Neurobiology, Duke University Medical Center, Durham, NC, USA.
Michele YeoDepartment of Neurobiology, Duke University Medical Center, Durham, NC, USA.
Christine ParkDepartment of Neurobiology, Duke University Medical Center, Durham, NC, USA.
Xiaolu YangDepartment of Neurobiology, Duke University Medical Center, Durham, NC, USA.ORCID http://orcid.org/0000-0003-4749-7803
Bor-Shuen WangCold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY, USA.
Derek G SouthwellDepartment of Neurobiology, Duke University Medical Center, Durham, NC, USA.
Z Josh HuangDepartment of Neurobiology, Duke University Medical Center, Durham, NC, USA. josh.huang@duke.edu.ORCID http://orcid.org/0000-0003-0592-028X
Duke University · USCold Spring Harbor Laboratory · US

Funding

Single-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI Tobias Janowitz · 1987 to 2026
$118.9M
Tool and Technology Development CoreU19MH114821 · NIMH · COLD SPRING HARBOR LABORATORY · PI ARLOTTA, PAOLA, HUANG, Z JOSH · 2017 to 2021
$64.5M
RNA-programmable cell-type targeting, editing, and therapyDP1MH129954 · NIMH · DUKE UNIVERSITY · PI HUANG, Z JOSH · 2021 to 2025
$5.6M
RNA-programmable cell type targeting and manipulation across vertebrate nervous systemsUF1MH128337 · NIMH · DUKE UNIVERSITY · PI HUANG, Z JOSH · 2021 to 2021
$586k
NCI NIH HHS P30 CA045508NIMH NIH HHS DP1 MH129954NIMH NIH HHS U19 MH114821NIMH NIH HHS UF1 MH128337
6 · The paper itself

Abstract

RNA is a central and universal mediator of genetic information underlying the diversity of cell types and cell states, which together shape tissue organization and organismal function across species and lifespans. Despite numerous advances in RNA sequencing technologies and the massive accumulation of transcriptome datasets across the life sciences

Indexed as

RNARNA EditingAnimalsBehavior, AnimalBrainHumansMiceNeuronsProtein BiosynthesisRatsSequence Analysis, RNATranscriptomeRNA

Identifiers

PMID36198803
PMCPMC10348343
OpenAlexW4302028429

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.