ArticleNature2022
The γδ IEL effector API5 masks genetic susceptibility to Paneth cell death.
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Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 71 citations in OpenAlex.
- Crosstalk between the microbiota and intestinal γδ T cell compartments in health and IBD.Gut microbes · 2026Review
- Mucosal immunity: mechanism and application in cancer immunotherapy.Journal of hematology & oncology · 2026Review
- Tetrameric STAT5 regulates the formation of immune niche cells to protect stem cell regenerative repair against mucosal inflammation.Experimental & molecular medicine · 2026Article
- Type I and III interferons synergize with TNF to promote virally-triggered damage to the intestinal epithelium.bioRxiv : the preprint server for biology · 2026Article
- Paneth cells as orchestrators of epithelial barrier defense and emerging therapeutic targets in inflammatory bowel disease.Seminars in immunopathology · 2026Review
- Metabolic stress sensing by epithelial RXRα links westernization of diet with Crohn's disease.Cell metabolism · 2026Article
- Chronic enteritis triggered by diet westernization is driven by epithelial ATG16L1-mediated autophagy.Autophagy · 2026Article
- Δ133p53 isoform enhances TLR4 function to promote tumor growth.Carcinogenesis · 2025Article
- API5 Phosphorylation Promotes Antiviral Immunity by Inhibiting Degradation of Cytosolic RNA Sensor RLRs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Microbiota in inflammatory bowel disease: mechanisms of disease and therapeutic opportunities.Nature reviews. Microbiology · 2025Review
- Gene-environment interactions shape the host-microbial interface in inflammatory bowel disease.Nature immunology · 2025Review
- Article
- Dysregulation of γδ intraepithelial lymphocytes precedes Crohn's disease-like ileitis.Science immunology · 2025Article
- Single-cell analyses of intestinal epithelium reveal the dysregulation of gut immune microenvironment in systemic lupus erythematosus.Journal of translational medicine · 2025Article
- Autophagy and Bacterial infections.Autophagy reports · 2025Review
- A single-cell transcriptomic atlas elucidates the hair cycle and apoptosis mechanisms in goat hair follicles.Frontiers in cell and developmental biology · 2025Article
- Type I IFN Induces TCR-dependent and -independent Antimicrobial Responses in γδ Intraepithelial Lymphocytes.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Organoids as a tool to study homeostatic and pathological immune-epithelial interactions in the gut.Clinical and experimental immunology · 2024Review
- Ileal Paneth Cell Phenotype is a Cellular Biomarker for Pouch Complications in Ulcerative Colitis.Journal of Crohn's & colitis · 2024Article
- Intraepithelial Lymphocytes of the Intestine.Annual review of immunology · 2024Review
Corrections and comments
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Authors and funding
18 authors at 6 institutions in 1 country.
Yu Matsuzawa-IshimotoKimmel Center for Biology and Medicine at the Skirball Institute, New York University Grossman School of Medicine, New York, NY, USA.
Xiaomin YaoKimmel Center for Biology and Medicine at the Skirball Institute, New York University Grossman School of Medicine, New York, NY, USA.
Akiko KoidePerlmutter Cancer Center, NYU Langone Health, New York, NY, USA.
Beatrix M UeberheidePerlmutter Cancer Center, NYU Langone Health, New York, NY, USA.
Jordan E AxelradDivision of Gastroenterology and Hepatology, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-1951-7790
Bernardo S ReisLaboratory of Mucosal Immunology, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0002-6841-116X
Roham ParsaLaboratory of Mucosal Immunology, The Rockefeller University, New York, NY, USA.
Jessica A NeilKimmel Center for Biology and Medicine at the Skirball Institute, New York University Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-2824-3701
Joseph C DevlinDepartment of Microbiology, New York University Grossman School of Medicine, New York, NY, USA.
Eugene RudenskyKimmel Center for Biology and Medicine at the Skirball Institute, New York University Grossman School of Medicine, New York, NY, USA.
M Zahidunnabi DewanExperimental Pathology, Division of Advanced Research Technologies, New York University Grossman School of Medicine, New York, NY, USA.
Michael CammerMicroscopy Laboratory, Division of Advanced Research Technologies, New York University Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-4930-1739
Richard S BlumbergDivision of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9704-248X
Yi DingDepartment of Laboratory Medicine, Geisinger Health, Danville, PA, USA.
Kelly V RugglesInstitute for Systems Genetics, New York University Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-0152-0863
Daniel MucidaDepartment of Neurology, New York University Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-0000-0452
Shohei KoidePerlmutter Cancer Center, NYU Langone Health, New York, NY, USA. Shohei.Koide@nyulangone.org.ORCID http://orcid.org/0000-0001-5473-4358
Ken CadwellKimmel Center for Biology and Medicine at the Skirball Institute, New York University Grossman School of Medicine, New York, NY, USA. Ken.Cadwell@med.nyu.edu.ORCID http://orcid.org/0000-0002-5860-0661
New York University · USNYU Langone Health · USRockefeller University · USBrigham and Women's Hospital · USGeisinger Health System · USHoward Hughes Medical Institute · US
Funding
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ADRIANA HEGUY · 1985 to 2026
$83.1MEndoplasmic reticulum stress and intestinal inflammationR01DK088199 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI Richard S Blumberg · 2010 to 2026
$9.6MDiabetes, Digestive, and Kidney Diseases Extramural ResearchR01DK093668 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Ken Hashigiwa Cadwell · 2011 to 2026
$7.3MRedefining the role of autophagy in bacterial diseaseR01AI121244 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Ken Hashigiwa Cadwell · 2017 to 2026
$5.6MThe role of autophagy gene Atg16L1 in allogeneic hematopoietic stem cell transplantation - Resubmission - 1R01HL123340 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CADWELL, KEN HASHIGIWA, VAN DEN BRINK, MARCEL R M · 2015 to 2022
$5.2MMechanisms of MRSA intestinal colonizationR01AI140754 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SHOPSIN, BO · 2020 to 2024
$3.5MInteractions between helminth colonization and the gut microbiotaR01AI130945 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CADWELL, KEN HASHIGIWA · 2018 to 2022
$3.3MMechanisms of fungal involvement during intestinal diseaseR01DK124336 · NIDDK · UNIVERSITY OF UTAH · PI ROUND, JUNE LOUISE · 2020 to 2023
$1.8MThe Role of Enteric Infection in Flares of Inflammatory Bowel DiseaseK23DK124570 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI AXELRAD, JORDAN ERIC · 2021 to 2025
$998kActivating Rural Clinics and Women with Disabilities to Improve Cancer ScreeningR21CA167087 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI BUCKLEY, DAVID · 2013 to 2014
$363kHoward Hughes Medical InstituteNCI NIH HHS P30 CA016087NCI NIH HHS R21 CA167087NHLBI NIH HHS R01 HL123340NIAID NIH HHS R01 AI121244NIAID NIH HHS R01 AI130945NIAID NIH HHS R01 AI140754NIDDK NIH HHS K23 DK124570NIDDK NIH HHS R01 DK088199NIDDK NIH HHS R01 DK093668NIDDK NIH HHS R01 DK124336
Abstract
Loss of Paneth cells and their antimicrobial granules compromises the intestinal epithelial barrier and is associated with Crohn's disease, a major type of inflammatory bowel disease
Indexed as
Apoptosis Regulatory ProteinsCrohn DiseaseGenetic Predisposition to DiseaseIntraepithelial LymphocytesNuclear ProteinsPaneth CellsAllelesAnimalsAutophagy-Related ProteinsCell DeathCell SurvivalHumansIntestinal MucosaMiceOrganoidsReceptors, Antigen, T-CellAPI5 protein, humanApi5 protein, mouseApoptosis Regulatory ProteinsATG16L1 protein, humanAtg16l1 protein, mouseAutophagy-Related ProteinsNuclear ProteinsReceptors, Antigen, T-Cell
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.