Evidence map›Paper›PMID 36198709›Full record

ArticleScientific reports2022

AHR is a master regulator of diverse pathways in endogenous metabolism.

Jeffry C Granados, Kian Falah, Imhoi Koo, Ethan W Morgan, Gary H Perdew, Andrew D Patterson, Neema Jamshidi, Sanjay K Nigam

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 61 citations in OpenAlex.

  1. Trial
  2. Article
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  4. Review
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  6. Review
  7. Article
  8. Article
  9. Article
  10. Why are long-lived plasma cells long-lived?Frontiers in immunology · 2026
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Habitual caffeine intake, genetics and cognitive performance.Journal of psychopharmacology (Oxford, England) · 2025
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jeffry C GranadosDepartment of Bioengineering, University of California San Diego, La Jolla, CA, 92093, USA.
Kian FalahDepartments of Biology, University of California San Diego, La Jolla, CA, 92093, USA.
Imhoi KooDepartment of Veterinary and Biomedical Sciences, Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA, 16802, USA.
Ethan W MorganDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, State College, PA, 16801, USA.
Gary H PerdewDepartment of Veterinary and Biomedical Sciences, Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA, 16802, USA.
Andrew D PattersonDepartment of Veterinary and Biomedical Sciences, Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA, 16802, USA.
Neema JamshidiDepartment of Radiological Sciences, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Sanjay K NigamDepartment of Pediatrics, University of California San Diego, La Jolla, CA, 92093, USA. snigam@health.ucsd.edu.
Pennsylvania State University · USUniversity of California, San Diego · USUniversity of California, Los Angeles · US

Funding

Activation of the Ah receptor and epithelial integrityR35ES028244 · NIEHS · PENNSYLVANIA STATE UNIVERSITY, THE · PI PERDEW, GARY H. · 2017 to 2024
$6.2M
Training in Multi-Scale Analysis of Biological Structure and FunctionT32EB009380 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrew D. McCulloch, Padmini Rangamani · 2009 to 2026
$4.8M
The Role of OAT1 in UremiaR01DK109392 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIGAM, SANJAY K · 2017 to 2025
$3.8M
Role of the renal organic anion transporter OAT1 in metabolism and physiologyR01GM132938 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIGAM, SANJAY K · 2019 to 2022
$2.0M
Environmental Ah Receptor Ligand Impact on the Host-Microbiome Metabolic AxisR01ES028288 · NIEHS · PENNSYLVANIA STATE UNIVERSITY, THE · PI PATTERSON, ANDREW · 2017 to 2021
$1.7M
NIDDK NIH HHS R01 DK109392NIEHS NIH HHS R01 ES028288NIEHS NIH HHS R35 ES028244NIGMS NIH HHS R01 GM132938
6 · The paper itself

Abstract

The aryl hydrocarbon receptor (AHR) is a transcription factor with roles in detoxification, development, immune response, chronic kidney disease and other syndromes. It regulates the expression of drug transporters and drug metabolizing enzymes in a proposed Remote Sensing and Signaling Network involved in inter-organ communication via metabolites and signaling molecules. Here, we use integrated omics approaches to analyze its contributions to metabolism across multiple scales from the organ to the organelle. Global metabolomics analysis of Ahr

Indexed as

AntioxidantsReceptors, Aryl HydrocarbonAnimalsBasic Helix-Loop-Helix ProteinsBile Acids and SaltsCholineHumansLigandsMiceAHR protein, humanAhr protein, mouseAntioxidantsBasic Helix-Loop-Helix ProteinsBile Acids and SaltsCholineLigandsReceptors, Aryl Hydrocarbon

Identifiers

PMID36198709
PMCPMC9534852
OpenAlexW4302004404

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.