ArticleNature communications2022
A pilot study combining noninvasive spinal neuromodulation and activity-based neurorehabilitation therapy in children with cerebral palsy.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Noninvasive Spinal Neuromodulation Enables Locomotor Recovery in Individuals With Cerebral Palsy
Transcutaneous Spinal Cord Stimulation to Improve Strength and Gait in Children With Spina Bifida
Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Motor Recovery After a Hemispherectomy: Review of Mechanisms and the Potential of Neuromodulation to Enhance Motor Outcomes.Journal of child neurology · 2026Review
- Feasibility and Safety of Combined Robot-Assisted Gait Training and Transcutaneous Spinal Cord Stimulation in Pediatric Incomplete Spinal Cord Injury: A Case Series.Children (Basel, Switzerland) · 2026Article
- Reopening Motor Learning Windows: Targeted Re-Engagement of Latent Pathways via Non-Invasive Neuromodulation.Life (Basel, Switzerland) · 2026Review
- The role of independent walking in the maturation of the spinal locomotor output in children with cerebral palsy.Frontiers in physiology · 2026Article
- Effectiveness of Electrical Stimulation on Upper Limb Function in Children and Young People with Hemiplegic Cerebral Palsy: A Systematic Review.Journal of clinical medicine · 2025Review
- Transcutaneous stimulation of the cervical spinal cord facilitates motoneuron firing and improves hand-motor function after spinal cord injury.Journal of neurophysiology · 2025Article
- The ins and outs of spinal cord stimulation.Brain communications · 2025Article
- Transcutaneous Spinal Stimulation Combined with Locomotor Training Improves Functional Outcomes in a Child with Cerebral Palsy: A Case Study.Children (Basel, Switzerland) · 2024Article
- Beyond pediatrics: noninvasive spinal neuromodulation improves motor function in an adult with cerebral palsy.Bioelectronic medicine · 2024Article
- Article
- Electrical Stimulation Exercise for People with Spinal Cord Injury: A Healthcare Provider Perspective.Journal of clinical medicine · 2023Review
- First Use of Non-Invasive Spinal Cord Stimulation in Motor Rehabilitation of Children with Spinal Muscular Atrophy.Life (Basel, Switzerland) · 2023Article
- Case study: persistent recovery of hand movement and tactile sensation in peripheral nerve injury using targeted transcutaneous spinal cord stimulation.Frontiers in neuroscience · 2023Article
- Combining spinal neuromodulation and activity based neurorehabilitation therapy improves sensorimotor function in cerebral palsy.Frontiers in rehabilitation sciences · 2023Article
- sPinal cOrd neUromodulatioN to treat Cerebral palsy in pEdiatrics: POUNCE Multisite Randomized Clinical Trial.Frontiers in neuroscience · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Cerebral Palsy (CP) is the most common pediatric motor disability with multiple symptoms and etiologies. CP is exhibited through sensorimotor delays, impaired posture resulting in limited activities and participation. Our recently concluded, single arm, unblinded, pilot study (NCT04882592) explored whether an intervention combining non-invasive spinal neuromodulation during an activity-based neurorehabilitation therapy (ABNT) can improve voluntary sensory-motor function captured via the Gross Motor Function Measure (GMFM-88) scores (primary outcome). Sixteen children diagnosed with CP with Gross Motor Function Classification Scale levels I-V were recruited and received the same intervention (2x/week for 8 weeks) to correct the dysfunctional connectivity between supraspinal and spinal networks using the normally developed proprioception. We demonstrate that the intervention was associated with clinically and statistically significant improvement in GMFM-88 scores in all children, thus meeting the prespecified primary endpoint. However, the improvement with ABNT alone needs further exploration. No serious adverse events were observed (safety endpoint).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.