Evidence map›Paper›PMID 36198483›Full record

ArticleJournal of clinical pathology2023

Preferential

Olivier T Giger, Rogier Ten Hoopen, David Shorthouse, Shukri Abdullahi, Venkata Ramesh Bulusu, Saili Jadhav, Eamonn R Maher, Ruth T Casey

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical pathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Phosphodiesterase 3 A expression in gastrointestinal stromal tumors.Virchows Archiv : an international journal of pathology · 2025
    Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Olivier T GigerPathology, University of Cambridge, Cambridge, UK olivier.giger@nhs.net.ORCID http://orcid.org/0000-0003-3390-6397
Rogier Ten HoopenOncology, University of Cambridge, Cambridge, UK.
David ShorthouseDepartment of Medical Physics and Biomedical Engineering, University College London, London, UK.ORCID http://orcid.org/0000-0002-3207-3584
Shukri AbdullahiPathology, University of Cambridge, Cambridge, UK.
Venkata Ramesh BulusuOncology, Addenbrooke's Hospital, Cambridge, UK.
Saili JadhavOncology, University of Cambridge, Cambridge, UK.
Eamonn R MaherDepartment of Medical Genetics and Cancer Research, University of Cambridge, Cambridge, UK.
Ruth T CaseyDepartment of Medical Genetics and Cancer Research, University of Cambridge, Cambridge, UK.
University of Cambridge · GBAddenbrooke's Hospital · GBUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsWild-type gastrointestinal stromal tumours (wtGIST) are frequently caused by inherited pathogenic variants, or somatic alterations in the succinate dehydrogenase subunit genes (

methodsMGMT methylation analysis was performed on 65 tumour samples including 47 wtGIST (33 SDH-deficient wtGIST and 11 SDH preserved wtGIST) and 21 tyrosine kinase (TK) mutant GIST.

results

conclusionMGMT promoter hypermethylation occurs exclusively in a subset of dSDH wtGIST. Data from this study support testing of tumour MGMT promoter methylation in patients with dSDH wtGIST to identify those patients who may benefit from most from TMZ therapy.

Indexed as

Gastrointestinal Stromal TumorsSuccinate DehydrogenaseDNA MethylationDNA Modification MethylasesDNA Repair EnzymesEpigenesis, GeneticHumansMutationProtein-Tyrosine KinasesTumor Suppressor ProteinsDNA Modification MethylasesDNA Repair EnzymesMGMT protein, humanProtein-Tyrosine KinasesSuccinate DehydrogenaseTumor Suppressor ProteinsGastrointestinal NeoplasmsNeoplastic Syndromes, HereditaryNeuroendocrine TumorsSarcomaStomach Neoplasms

Identifiers

PMID36198483
PMCPMC10804026
OpenAlexW4302013571

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.