ArticleBMJ open2022
Recontacting biobank participants to collect lifestyle, behavioural and cognitive information via online questionnaires: lessons from a pilot study within FinnGen.
Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Dietary intervention and BMI reduction in individuals at the extremes of genetic predisposition to higher BMI: a randomized controlled trial.Nature communications · 2026Trial
- Biobank-based genetic characterization of neurodegenerative diseases and idiopathic normal pressure hydrocephalus: insights and lessons learned from FinnGen.Molecular psychiatry · 2026Review
- Evaluation of the genome-informed risk assessment (GIRA) approach from eMERGE in an independent health system.medRxiv : the preprint server for health sciences · 2026Article
- Inclusion bias affects common variant discovery and replication in a health-system linked biobank.American journal of human genetics · 2026Article
- Genetic, lifestyle and environmental influences on health: a Finnish biobank recall study protocol (BioRecall).BMJ open · 2026Article
- Integration of former child and adolescent study participants into a national health online panel for a longitudinal study on young adult mental health.BMC medical research methodology · 2025Article
- Perceived risk of type 2 diabetes: Using linked genomic, clinical and questionnaire data to understand the potential use of genetic risk tools in British South Asians.PLOS global public health · 2025Article
- Observational
- Cohort Profile Update: Mental Health Online Survey in the Estonian Biobank (EstBB MHoS).International journal of epidemiology · 2024Article
- TWINGEN - protocol for an observational clinical biobank recall and biomarker study to identify individuals with high risk of Alzheimer's disease.medRxiv : the preprint server for health sciences · 2023Article
- A FinnGen pilot clinical recall study for Alzheimer's disease.Scientific reports · 2023Article
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Authors and funding
26 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo recontact biobank participants and collect cognitive, behavioural and lifestyle information via a secure online platform.
designBiobank-based recontacting pilot study.
settingThree Finnish biobanks (Helsinki, Auria, Tampere) recruiting participants from February 2021 to July 2021.
participantsAll eligible invitees were enrolled in FinnGen by their biobanks (Helsinki, Auria, Tampere), had available genetic data and were >18 years old. Individuals with severe neuropsychiatric disease or cognitive or physical disabilities were excluded. Lastly, 5995 participants were selected based on their polygenic score for cognitive abilities and invited to the study. Among invitees, 1115 had successfully participated and completed the study questionnaire(s). OUTCOME MEASURES: The primary outcome was the participation rate among study invitees. Secondary outcomes included questionnaire completion rate, quality of data collected and comparison of participation rate boosting strategies.
resultsThe overall participation rate was 18.6% among all invitees and 23.1% among individuals aged 18-69. A second reminder letter yielded an additional 9.7% participation rate in those who did not respond to the first invitation. Recontacting participants via an online healthcare portal yielded lower participation than recontacting via physical letter. The completion rate of the questionnaire and cognitive tests was high (92% and 85%, respectively), and measurements were overall reliable among participants. For example, the correlation (r) between self-reported body mass index and that collected by the biobanks was 0.92.
conclusionIn summary, this pilot suggests that recontacting FinnGen participants with the goal to collect a wide range of cognitive, behavioural and lifestyle information without additional engagement results in a low participation rate, but with reliable data. We suggest that such information be collected at enrolment, if possible, rather than via post hoc recontacting.
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