Evidence map›Paper›PMID 36198343›Full record

ArticlePhysiology & behavior2023

Rat offspring's microbiota composition is predominantly shaped by the postnatal maternal diet rather than prenatal diet.

Ruth Schade, Lin Song, Zachary A Cordner, Hua Ding, Daniel A Peterson, Timothy H Moran, Kellie L Tamashiro, Claire B de La Serre

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiology & behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Ruth SchadeDepartment of Nutritional Sciences, University of Georgia, Athens, GA, U.S.A; Current address: Department of Microbiology and Immunology, Stanford University, Palo Alto, CA, U.S.A.
Lin SongDepartments of Psychiatry & Behavioral Science, Johns Hopkins University School of Medicine, Baltimore, MD, U.S.A; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of China, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Zachary A CordnerDepartments of Psychiatry & Behavioral Science, Johns Hopkins University School of Medicine, Baltimore, MD, U.S.A.
Hua DingDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, U.S.A.
Daniel A PetersonDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, U.S.A.
Timothy H MoranDepartments of Psychiatry & Behavioral Science, Johns Hopkins University School of Medicine, Baltimore, MD, U.S.A.
Kellie L TamashiroDepartments of Psychiatry & Behavioral Science, Johns Hopkins University School of Medicine, Baltimore, MD, U.S.A. Electronic address: ktamashiro@jhmi.edu.
Claire B de La SerreDepartment of Nutritional Sciences, University of Georgia, Athens, GA, U.S.A. Electronic address: cdlserre@uga.edu.
Johns Hopkins University · USUniversity of Georgia · USXi'an Jiaotong University · CN

Funding

Maternal diet and programming of offspring gut-brain axisR01DK129193 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI KELLIE L. K. TAMASHIRO · 2022 to 2026
$2.9M
NIDDK NIH HHS R01 DK129193
6 · The paper itself

Abstract

This study assessed the impact of maternal diet during pregnancy versus lactation on offspring gut microbiota. Sprague-Dawley dams were fed high fat (HF) or Chow diets during pregnancy, and their male offspring were raised by a different dam consuming the same or opposite diet (Chow-Chow, Chow-HF, HF-Chow, and HF-HF). Microbiota analysis showed that maternal lactation diet, rather than pregnancy diet, determined offspring microbiota profiles at weaning. Increased abundances of Turicibacter, Staphylococcus , and Ruminococcus were characteristic of chow lactation groups. Lactococcus , Streptococcus , and Parabacteroides were characteristic of HF lactation groups and positively correlated with offspring body weight.

Indexed as

MicrobiotaPrenatal Exposure Delayed EffectsAnimalsBody WeightDietDiet, High-FatFemaleHumansLactationMaleMaternal Nutritional Physiological PhenomenaPregnancyRatsRats, Sprague-DawleyBody weightGut microbiotaLactationMaternal dietObesityOffspring

Identifiers

PMID36198343
PMCPMC10088501
OpenAlexW4300002586

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.