Evidence map›Paper›PMID 36198291›Full record

Trial reportCell metabolism2022

Feasibility of time-restricted eating and impacts on cardiometabolic health in 24-h shift workers: The Healthy Heroes randomized control trial.

Emily N C Manoogian, Adena Zadourian, Hannah C Lo, Nikko R Gutierrez, Azarin Shoghi, Ashley Rosander, Aryana Pazargadi, Cameron K Ormiston, Xinran Wang, Jialu Sui and 5 more

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled TrialVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cell metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03533023 (Optimizing Circadian Rhythms by Regulating Eating Patterns to Reduce Cardiometabolic Disease Risk Among Firefighters--The Healthy Heroes Study), which is not on this map. Cited by 117 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed, 15 pooled it
29.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03533023 nacompletednot on this map

Optimizing Circadian Rhythms by Regulating Eating Patterns to Reduce Cardiometabolic Disease Risk Among Firefighters--The Healthy Heroes Study

TypeinterventionalSponsorUniversity of California, San DiegoRan2018 to 2021Enrolled153ConditionsShift Workers' Health, Time Restricted Eating, FastingArmsTime Restricted Eating + Standard of Care, Standard of Care
3 · Its place in the literature

Who cites it

117 citing papers in PubMed, 15 syntheses or guidelines pooled it, 161 citations in OpenAlex.

  1. A Systematic Review of Nutrition Interventions for Shift Workers, With Subgroup Analysis of First Responder Populations.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026
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  17. A Qualitative Exploration of Facilitators and Barriers to Early Time-Restricted Eating: Insights From a Randomised Controlled Trial.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025
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57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Emily N C ManoogianRegulatory Biology, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Adena ZadourianDivision of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, San Diego, CA 92037, USA.
Hannah C LoDivision of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, San Diego, CA 92037, USA.
Nikko R GutierrezRegulatory Biology, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Azarin ShoghiRegulatory Biology, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Ashley RosanderDivision of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, San Diego, CA 92037, USA.
Aryana PazargadiDivision of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, San Diego, CA 92037, USA.
Cameron K OrmistonDivision of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, San Diego, CA 92037, USA.
Xinran WangRegulatory Biology, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Jialu SuiRegulatory Biology, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Zhaoyi HouRegulatory Biology, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Jason G FleischerDepartment of Cognitive Science, University of California, San Diego, San Diego, CA 92037, USA.
Shahrokh GolshanDepartment of Psychiatry, University of California, San Diego, San Diego, CA 92037, USA.
Pam R TaubDivision of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, San Diego, CA 92037, USA. Electronic address: ptaub@ucsd.edu.
Satchidananda PandaRegulatory Biology, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address: satchin@salk.edu.
University of California San Diego · USSalk Institute for Biological Studies · US

Funding

Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Alan Saghatelian · 1985 to 2026
$82.8M
Impact of Time-Restricted Feeding (TRF) on Glucose Homeostasis and Mitochondrial Function in Patients with Metabolic SyndromeR01DK118278 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Pam Rajendran Taub · 2018 to 2026
$5.3M
Impact of Time-Restricted Feeding in Reducing Cancer Risk Through Optimizing Mitochondria FunctionR01CA258221 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI PANDA, SATCHIDANANDA · 2021 to 2025
$3.8M
Pharmacological targeting of circadian clock components to treat glioblastomaR01CA236352 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI PANDA, SATCHIDANANDA · 2019 to 2023
$2.6M
NCI NIH HHS P30 CA014195NCI NIH HHS R01 CA236352NCI NIH HHS R01 CA258221NIDDK NIH HHS R01 DK118278
6 · The paper itself

Abstract

Over a quarter of the workforce in industrialized countries does shift work, which increases the risk for cardiometabolic disease. Yet shift workers are often excluded from lifestyle intervention studies to reduce this risk. In a randomized control trial with 137 firefighters who work 24-h shifts (23-59 years old, 9% female), 12 weeks of 10-h time-restricted eating (TRE) was feasible, with TRE participants decreasing their eating window (baseline, mean 14.13 h, 95% CI 13.78-14.47 h; intervention, 11.13 h, 95% CI 10.73-11.54 h, p = 3.29E-17) with no adverse effects, and improved quality of life assessed via SF-36 (ClinicalTrials.gov: NCT03533023). Compared to the standard of care (SOC) arm, TRE significantly decreased VLDL particle size. In participants with elevated cardiometabolic risks at baseline, there were significant reductions in TRE compared to SOC in glycated hemoglobin A1C and diastolic blood pressure. For individuals working a 24-h shift schedule, TRE is feasible and can improve cardiometabolic health, especially for individuals with increased risk. VIDEO ABSTRACT.

Indexed as

Cardiovascular DiseasesQuality of LifeAdultBlood PressureFastingFeasibility StudiesFemaleGlycated HemoglobinHumansMaleMiddle AgedYoung AdultGlycated Hemoglobincircadiandiabetesfirefightershypertensionintermittent fastingquality of lifeshift worksleeptime-restricted eatingTRF

Identifiers

PMID36198291
PMCPMC9536325
OpenAlexW4300980060

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.