Evidence map›Paper›PMID 36198289›Full record

ArticleCell metabolism2022

Cap CASP, not SCAP, to fight steatohepatitis.

Wolfram Goessling

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Wolfram GoesslingGastroenterology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Genetics Division, Brigham and Women's Hospital, Boston, MA, USA; Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, USA. Electronic address: wgoessling@mgh.harvard.edu.

Funding

A Community Zebrafish Resource for Modeling GWAS BiologyR24OD017870 · OD · BRIGHAM AND WOMEN'S HOSPITAL · PI GOESSLING, WOLFRAM, MACRAE, CALUM A. · 2014 to 2021
$6.3M
Estrogen Regulation of Hepatic GrowthR01DK090311 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI GOESSLING, WOLFRAM · 2011 to 2020
$4.9M
Metabolic Regulation of Liver GrowthR01DK105198 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI GOESSLING, WOLFRAM · 2016 to 2020
$2.7M
NIDDK NIH HHS R01 DK090311NIDDK NIH HHS R01 DK105198NIH HHS R24 OD017870
6 · The paper itself

Abstract

Hepatic lipid synthesis through SREBP has recently been found to be regulated not only through the canonical pathway involving SCAP in response to sterol deficiency, but also through the PIDDosome and CASP2. In this issue, Kim et al. identify a novel interaction between these two pathways in diet-induced non-alcoholic steatohepatitis.

Indexed as

Fatty LiverIntracellular Signaling Peptides and ProteinsHumansMembrane ProteinsSterol Regulatory Element Binding Protein 1SterolsIntracellular Signaling Peptides and ProteinsMembrane ProteinsSterol Regulatory Element Binding Protein 1Sterols

Identifiers

PMID36198289

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.