Evidence map›Paper›PMID 36198287›Full record

ArticleCell metabolism2022

Dietary sugar lowers immunity and microbiota that protect against metabolic disease.

Han Fang, Fernando F Anhê, Jonathan D Schertzer

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Han FangDepartment of Biochemistry and Biomedical Sciences, Farncombe Family Digestive Health Research Institute, and Centre for Metabolism, Obesity and Diabetes Research, McMaster University, 1200 Main Street W., Hamilton, ON L8N 3Z5, Canada.
Fernando F AnhêQuebec Heart and Lung Institute (IUCPQ), Faculty of Medicine, Laval University, Québec City, QC G1V 4G5, Canada; Institute of Nutrition and Functional Foods (INAF), Laval University, Québec City, QC G1V 0A6, Canada.
Jonathan D SchertzerDepartment of Biochemistry and Biomedical Sciences, Farncombe Family Digestive Health Research Institute, and Centre for Metabolism, Obesity and Diabetes Research, McMaster University, 1200 Main Street W., Hamilton, ON L8N 3Z5, Canada. Electronic address: schertze@mcmaster.ca.
Digestive Health Research Institute · FRInstitut universitaire de cardiologie et de pneumologie de Québec · CAMcMaster University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diet influences intestinal microbiota, inflammation, and metabolism. Kawano et al. show that dietary sugar engaged upper gut innate lymphoid cells to replace segmented filamentous bacteria with a pathobiont. Added sugar worsened early metabolic disease by lowering protective Th17 immunity, thereby promoting intestinal lipid absorption and obesity in high-fat-diet-fed mice.

Indexed as

Metabolic DiseasesMicrobiotaAnimalsDietary SugarsDiet, High-FatImmunity, InnateLipidsLymphocytesMiceMice, Inbred C57BLDietary SugarsLipids

Identifiers

PMID36198287
OpenAlexW4301185371

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.