ArticleCell reports2022
E-Cannula reveals anatomical diversity in sharp-wave ripples as a driver for the recruitment of distinct hippocampal assemblies.
Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- The hippocampus as a small-world cognitive map.bioRxiv : the preprint server for biology · 2026Article
- Dynamic neuronal ensembles encode burst-suppression revealed by cortex-wide optical-electrical interfaces.Nature communications · 2026Article
- Innovating beyond electrophysiology through multimodal neural interfaces.Nature reviews electrical engineering · 2025Article
- Atomically thin bioelectronics.Nature reviews. Materials · 2024Article
- Hippocampal recording with a soft microelectrode array in a cranial window imaging scheme: a validation study.Scientific reports · 2024Article
- Transformers and cortical waves: encoders for pulling in context across time.Trends in neurosciences · 2024Review
- Linking brain activity across scales with simultaneous opto- and electrophysiology.Neurophotonics · 2024Review
- Functional architecture of intracellular oscillations in hippocampal dendrites.Nature communications · 2024Article
- Multiphoton imaging of hippocampal neural circuits: techniques and biological insights into region-, cell-type-, and pathway-specific functions.Neurophotonics · 2024Review
- High-density transparent graphene arrays for predicting cellular calcium activity at depth from surface potential recordings.Nature nanotechnology · 2024Article
- A machine learning toolbox for the analysis of sharp-wave ripples reveals common waveform features across species.Communications biology · 2024Article
- Functional architecture of intracellular oscillations in hippocampal dendrites.bioRxiv : the preprint server for biology · 2024Article
- Topological analysis of sharp-wave ripple waveforms reveals input mechanisms behind feature variations.Nature neuroscience · 2023Article
- A machine learning toolbox for the analysis of sharp-wave ripples reveal common features across species.bioRxiv : the preprint server for biology · 2023Article
- Transparent neural interfaces: challenges and solutions of microengineered multimodal implants designed to measure intact neuronal populations using high-resolution electrophysiology and microscopy simultaneously.Microsystems & nanoengineering · 2023Review
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Authors and funding
8 authors.
Funding
Abstract
The hippocampus plays a critical role in spatial navigation and episodic memory. However, research on in vivo hippocampal activity dynamics mostly relies on single modalities, such as electrical recordings or optical imaging, with respectively limited spatial and temporal resolution. Here, we develop the E-Cannula, integrating fully transparent graphene microelectrodes with imaging cannula, which enables simultaneous electrical recording and two-photon calcium imaging from the exact same neural populations across an anatomically extended region of the mouse hippocampal CA1 stably across several days. The large-scale multimodal recordings show that sharp wave ripples (SWRs) exhibit spatiotemporal wave patterns along multiple axes in two-dimensional (2D) space with different spatial extents and temporal propagation modes. Notably, distinct SWR wave patterns are associated with the selective recruitment of orthogonal CA1 cell assemblies. These results demonstrate the utility of the E-Cannula as a versatile neurotechnology with the potential for future integration with other optical components.
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