ArticleNeurobiology of aging2022
Behavioral and fMRI evidence that arousal enhances bottom-up selectivity in young but not older adults.
Article in Neurobiology of aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Eye movement evidence for locus coeruleus-noradrenaline system contributions to age differences in attention.Psychology and aging · 2025Article
- Neuromelanin-sensitive MRI for mechanistic research and biomarker development in psychiatry.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Functional locus coeruleus imaging to investigate an ageing noradrenergic system.Communications biology · 2024Article
- Eye movements reveal age differences in how arousal modulates saliency priority but not attention processing speed.bioRxiv : the preprint server for biology · 2024Article
- Age-related reductions in arousal-enhanced memory are moderated by trait emotion regulation.Scientific reports · 2023Article
- The integrity of dopaminergic and noradrenergic brain regions is associated with different aspects of late-life memory performance.Nature aging · 2023Article
- Effects of Adult Age and Functioning of the Locus Coeruleus Norepinephrinergic System on Reward-Based Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Characterization of an automated method to segment the human locus coeruleus.Human brain mapping · 2023Article
- Isometric handgrip exercise speeds working memory responses in younger and older adults.Psychology and aging · 2023Article
- Locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant Alzheimer's disease.Neurobiology of aging · 2022Article
- Age-Related Intrinsic Functional Connectivity Changes of Locus Coeruleus from Childhood to Older Adults.Brain sciences · 2021Article
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Abstract
The locus coeruleus-noradrenergic system integrates signals about arousal states throughout the brain and helps coordinate cognitive selectivity. However, age-related changes in this system may impact how arousal coordinates selectivity in older adults. To examine this, we compared how increases in emotional arousal modulates cognitive selectivity for images differing in perceptual salience in young and older adults. Using functional magnetic resonance imaging, we found that relative to older adults, hearing an arousing sound enhanced young adults' bottom-up processing and incidental memory for high versus low salience category-selective body images. We also examined how arousing sounds impacted a top-down goal to detect dot-probes that appeared immediately after high or low salience images. We found that young adults were slower to detect probes appearing after high salience body images on arousing trials, whereas older adults showed this pattern on non-arousing trials. Taken together, our findings show that arousal's effect on selectivity changes with age and differs across bottom-up and top-down processing.
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