SynthesisJCO global oncology2022
Outcomes of Children With Low-Grade Gliomas in Low- and Middle-Income Countries: A Systematic Review.
Synthesis in JCO global oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Incidence and survival of pediatric low-grade gliomas in Switzerland.World journal of pediatrics : WJP · 2026Article
- Tempered optimism: Advances in the precision medicine era for pediatric low-grade glioma.Neuro-oncology · 2026Review
- Online Outcomes of a Pediatric Neuro-Oncology Course for Multidisciplinary Healthcare Professionals in Low- and Middle-Income Countries.Journal of cancer education : the official journal of the American Association for Cancer Education · 2026Article
- "From misdiagnosis to precision medicine: strengthening pediatric neuro-oncology care in LMICs toward equitable pLGG outcomes".Frontiers in oncology · 2026Review
- Childhood cancer survival in low- and middle-income countries and the Global South: emerging evidence and critical gaps from a scoping review of observational studies.EJC paediatric oncology · 2025Review
- Ten years of pediatric low-grade glioma care in Kenya: Outcomes, progress, and gaps toward achieving global childhood cancer equity.Neuro-oncology pediatrics · 2025Article
- Surgical treatment of pediatric low-grade glioma in developing countries.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Review
- Low-grade glioma of the temporal lobe and tumor-related epilepsy in children.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Review
- The greatest challenge for pediatric low-grade glioma.Neuro-oncology · 2024Article
- Trends in pediatric CNS tumors in Armenia: a multicenter retrospective study.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Challenges in treating children with optic pathway gliomas: an 18-year experience from a middle-income country.Frontiers in oncology · 2024Article
- Therapeutic results in children with brain tumors - a single center experience over 18 years.Medicine and pharmacy reports · 2024Article
- Tackling Pediatric Low-Grade Gliomas: A Global Perspective.JCO global oncology · 2023Article
- The role of neurosurgery in advancing pediatric CNS tumor care worldwide.Brain & spine · 2023Review
- Pediatric Neurosurgical Capacity for the Care of Children With CNS Tumors Worldwide: A Cross-Sectional Assessment.JCO global oncology · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
purposePediatric CNS tumors are increasingly a priority, particularly with the WHO designation of low-grade glioma (LGG) as one of six index childhood cancers. There are currently limited data on outcomes of pediatric patients with LGGs in low- and middle-income countries (LMICs).
methodsTo better understand the outcomes of LGGs in LMICs, this systematic review interrogated nine literature databases.
resultsThe search identified 14,977 publications. Sixteen studies from 19 countries met the selection criteria and were included for data abstraction and analysis. Eleven studies (69%) were retrospective reviews from single institutions, and one (6%) captured institutional data prospectively. The studies captured a total of 957 patients with a median of 49 patients per study. Seven (44%) of the studies described the treatment modalities used. Of 373 patients for whom there was information, 173 (46%) had a gross total or near total resection, 109 (29%) had a subtotal resection, and 91 (24%) had only a biopsy performed. Seven studies, with a total of 476 patients, described the frequency of use of radiotherapy and/or chemotherapy in the cohorts: 83 of these patients received radiotherapy and 76 received chemotherapy. The 5-year overall survival ranged from 69.2% to 93.5%, although lower survival rates were reported at earlier time points. We identified limitations in the published studies with respect to the cohort sizes and methodologies.
conclusionThe included studies reported survival rates frequently exceeding 80%, although the ultimate number of studies was limited, pointing to the paucity of studies describing the outcomes of children with LGGs in LMICs. This study underscores the need for more robust data on outcomes in pediatric LGG.
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