Evidence map›Paper›PMID 36197647›Full record

Trial reportClinical rheumatology2023

Genicular nerve block in juvenile idiopathic arthritis: a randomized clinical trial.

A Radwan, S Ohrndorf, H Aly, M Hamed, A Khalifa, A M Elsaman

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical rheumatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04687930 (Genicular Nerve Block in Juvenile Idiopathic Arthritis), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04687930 phase4completednot on this map

Genicular Nerve Block in Juvenile Idiopathic Arthritis

TypeinterventionalSponsorSohag UniversityRan2020 to 2021Enrolled104ConditionsJuvenile Idiopathic Arthritis, Persistent Knee Arthritis, no Intra-articular Injection in the Last 3 Months, no Other Cause for Chronic KneearthritisArmsgenicular nerve block, intra-articular steroid injection
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

A RadwanDepartment of Rheumatology and Rehabilitation, Sohag University Hospital, Akhmim- Elsawmaa St, Sohag, 82524, Egypt.
S OhrndorfDepartment of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
H AlyDepartment of Rheumatology and Rehabilitation, Al-Azhar University, Cairo, Egypt.
M HamedDepartment of Radiology, Sohag University Hospital, Sohag, Egypt.
A KhalifaDepartment of Rheumatology and Rehabilitation, Sohag University Hospital, Akhmim- Elsawmaa St, Sohag, 82524, Egypt.
A M ElsamanDepartment of Rheumatology and Rehabilitation, Sohag University Hospital, Akhmim- Elsawmaa St, Sohag, 82524, Egypt. Ahmed_elsaman@med.sohag.edu.eg.ORCID http://orcid.org/0000-0001-5759-2009
Sohag University · EGAl-Azhar University · EGCharité - Universitätsmedizin Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aimed at evaluating the effect of genicular nerve block (GNB) in juvenile idiopathic arthritis (JIA) patients with persistent unilateral knee arthritis on pain, inflammatory parameters, function, and range of motion.

methodsA total of 104 JIA patients were diagnosed according to the International League Against Rheumatism (ILAR) criteria with persistent unilateral knee arthritis. They were allocated randomly into 2 groups: group 1 treated with GNB, while group 2 was treated with intra-articular triamcinolone (TA) only. Visual analogue scale (VAS) on pain, sonography of large joints in rheumatology (SOLAR) scoring system, and Lysholm scores were assessed at 0-, 2-, and 12-week intervals. Swelling and tenderness were clinically evaluated semi-quantitatively (0-3) at the same time intervals.

resultsVAS pain, tenderness, swelling, and SOLAR grey scale (GS) and power Doppler (PD) scores were significantly reduced after 2 weeks in both groups (p < 0.05). This was greater in the GNB group regarding VAS and tenderness, while SOLAR and swelling were stronger reduced in TA group. After 12 weeks, all outcome measures showed lower values in the GNB group compared to TA, and this was significant regarding VAS pain. Moreover, Lysholm functional score was significantly increased in both groups at both intervals; and higher values were seen in the TA group compared to GNB after 2 weeks.

conclusionGNB was able to control pain and improve function and inflammation of the knee joint in JIA patients. Though steroid attained better results after 2 weeks, GNB achieved an equivalent longer-term improvement after 12 weeks. TRIAL REGISTRATION IDENTIFYING NUMBER: NCT04687930. Key Points • Persistent knee arthritis treatment in JIA is always challenging. • GNB was approved for treatment of pain in knee osteoarthritis. • GNB in the present study succeeded to control active knee arthritis and this effect was comparable to intra-articular steroid injection.

Indexed as

Arthritis, JuvenileNerve BlockOsteoarthritis, KneeHumansInjections, Intra-ArticularKnee JointPainTreatment OutcomeTriamcinoloneTriamcinoloneGenicular nerve blockJuvenile idiopathic arthritis

Identifiers

PMID36197647
PMCPMC9935707
OpenAlexW4301606467

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.