ArticleMikrochimica acta2022
Multi pathogenic microorganisms determination using DNA composites-encapsulated DNA silver nanocluster/graphene oxide-based system through rolling cycle amplification.
Article in Mikrochimica acta, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 20 citations in OpenAlex.
- Advances in methods for rapid detection of Staphylococcus aureus and methicillin-resistant S. aureus.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025Review
- Recent Advances in the Development of Functional Nucleic Acid Biosensors Based on Aptamer-Rolling Circle Amplification.Molecules (Basel, Switzerland) · 2025Review
- Facile Splint-Free Circularization of ssDNA with T4 DNA Ligase by Redesigning the Linear Substrate to Form an Intramolecular Dynamic Nick.Biomolecules · 2024Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
A multi pathogenic microorganisms determination method is reported using DNA composites encapsulated DNA silver nanocluster (AgNCs)/graphene oxide (GO)-based system through rolling cycle (RCA) amplification. Firstly, two different RCA-based DNA composites are assembled, coupled with thousands of DNA-stabilized AgNCs probe and ssDNA aptamer specific for two pathogen bacteria targets. GO was then introduced into the system to capture ssDNA aptamer of DNA composites and as a selective fluorescence quencher of DNA/AgNCs. Upon recognizing the target bacteria, ssDNA aptamer part would combine with bacteria and release from the surface of GO. Thus, DNA/AgNCs of RCA-based DNA composites can generate strong fluorescence signal. With the fluorescent report of RCADNA-AgNCs/530 and RCADNA-AgNCs/625, the assay successfully detect Escherichia coli and Staphylococcus aureus at concentrations as low as 38 CFU/mL, and a highly selective and efficient sensing platform was achieved. Therefore, this RCA/DNA-AgNCs/GO-based platform shows excellent application in multi pathogenic microorganisms determination and potential clinic therapy.
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Registered trials
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