Evidence map›Paper›PMID 36197563›Full record

ArticleEuropean journal of epidemiology2022

Breast cancer risk in Ukrainian women exposed to Chornobyl fallout while pregnant or lactating: standardized incidence ratio analysis, 1998 to 2016.

Vibha Vij, Victor Shpak, Galyna Zamotayeva, Oles Lapikura, Anton Ryzhov, Evgeniy Gorokh, Rui Zhang, Kiyohiko Mabuchi, Mark P Little, Vladimir Drozdovitch and 5 more

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In one paragraph

Article in European journal of epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Vibha VijRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Bethesda, MD, 20892-9778, USA. vibha.vij@nih.gov.ORCID http://orcid.org/0000-0002-1411-0257
Victor ShpakV.P. Komisarenka Institute of Endocrinology and Metabolism, National Academy of Medical Sciences of Ukraine, Kyiv, 04114, Ukraine.
Galyna ZamotayevaV.P. Komisarenka Institute of Endocrinology and Metabolism, National Academy of Medical Sciences of Ukraine, Kyiv, 04114, Ukraine.
Oles LapikuraV.P. Komisarenka Institute of Endocrinology and Metabolism, National Academy of Medical Sciences of Ukraine, Kyiv, 04114, Ukraine.
Anton RyzhovTaras Shevchenko National University of Kyiv, Kyiv, 01033, Ukraine.
Evgeniy GorokhNational Cancer Registry of Ukraine, National Cancer Institute, Kyiv, 03022, Ukraine.
Rui ZhangRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Bethesda, MD, 20892-9778, USA.
Kiyohiko MabuchiRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Bethesda, MD, 20892-9778, USA.
Mark P LittleRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Bethesda, MD, 20892-9778, USA.
Vladimir DrozdovitchRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Bethesda, MD, 20892-9778, USA.
Konstantin ChizhovRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Bethesda, MD, 20892-9778, USA.
Sergii MasuikNational Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, Kyiv, 04050, Ukraine.
Dale PrestonHirosoft International, Eureka, CA, USA.
Mykola TronkoV.P. Komisarenka Institute of Endocrinology and Metabolism, National Academy of Medical Sciences of Ukraine, Kyiv, 04114, Ukraine.
Elizabeth K CahoonRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Bethesda, MD, 20892-9778, USA.

Funding

Studies of Populations Exposed to Environmental Sources of RadiationZIACP010132 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI CAHOON, ELIZABETH · 2009 to 2025
$35.2M
CLC NIH HHS C0000008Intramural NIH HHS ZIA CP010132
6 · The paper itself

Abstract

The radiation-related risk of breast cancer among women following the Chornobyl accident remains uncertain. During pregnancy, there is rapid cell proliferation in the breast while radioactive iodine from fallout exposure can concentrate in lactating breast tissues. We conducted a standardized incidence ratio (SIR) analysis of breast cancer in a cohort of 2,631 women who were lactating and/or pregnant at any time during the 2-month period of radioiodine fallout (April 26, 1986-June 30, 1986). There were 37,151 person-years of follow-up, and 26 incident breast cancers were identified through linkage with the National Cancer Registry of Ukraine. Breast cancer rates among pregnant or lactating women were compared to the general population rates, and SIRs were adjusted for oblast, urban/rural, age, and calendar year. The SIR was not significant for women pregnant at the time of the accident (SIR = 0.75; 95% CI 0.44, 1.18) or for women lactating anytime within 2 months of the accident (SIR = 0.96; 95% CI 0.48, 1.68). However, there was a non-significantly elevated risk for women lactating at the time of accident (SIR = 1.30, 95% CI 0.40, 3.01). The increased SIR for breast cancer among lactating women is consistent with the results of a similar study in Belarus and indicates the need to quantify the radiation risk of breast cancer in a larger study of women lactating during the period of fallout exposure.

Indexed as

Breast NeoplasmsChernobyl Nuclear AccidentNeoplasms, Radiation-InducedThyroid NeoplasmsEastern European PeopleFemaleHumansIncidenceIodine RadioisotopesLactationPregnancyUkraineIodine RadioisotopesBreast cancerBreastfeedingChernobylChornobylLactationPregnancyRadiationUkraine

Identifiers

PMID36197563
PMCPMC10655931

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.