Evidence map›Paper›PMID 36197499›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2023

Human biodistribution and radiation dosimetry of the demyelination tracer [

Pedro Brugarolas, Moses Q Wilks, Jacqueline Noel, Julia-Ann Kaiser, Danielle R Vesper, Karla M Ramos-Torres, Nicolas J Guehl, Marina T Macdonald-Soccorso, Yang Sun, Peter A Rice and 4 more

Open access · hybridAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. First evaluation in multiple sclerosis using PET tracer [European journal of nuclear medicine and molecular imaging · 2026
    Article
  4. Review
  5. Review
  6. Imaging Demyelinated Axons After Spinal Cord Injuries with PET Tracer [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  7. Synthesis of KBioorganic & medicinal chemistry letters · 2024
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Metabolic Stability of the Demyelination Positron Emission Tomography Tracer [The Journal of pharmacology and experimental therapeutics · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Pedro Brugarolas *Department of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA. pbrugarolas@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-7455-2743
Moses Q WilksDepartment of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Jacqueline NoelDepartment of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Julia-Ann KaiserDepartment of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Danielle R VesperDepartment of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Karla M Ramos-TorresDepartment of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Nicolas J GuehlDepartment of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Marina T Macdonald-SoccorsoDepartment of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Yang SunDepartment of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Peter A RiceDepartment of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Daniel L YokellDepartment of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Ruth LimDepartment of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Marc D NormandinDepartment of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Georges El FakhriDepartment of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA. elfakhri.georges@mgh.harvard.edu.
Harvard University · US

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTOPHER P DUGGAN · 1994 to 2026
$31.6M
Unified Joint Statistical Reconstruction of PET & MRP41EB022544 · NIBIB · YALE UNIVERSITY · PI Kira Grogg · 2017 to 2026
$14.8M
Can [18F]3F4AP Detect Brain Demyelination? Evaluation of Novel PET Tracer in Nonhuman Primates and HumansR01NS114066 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI BRUGAROLAS, PEDRO · 2020 to 2024
$1.8M
System for Synthesis of PET RadiopharmaceuticalsS10OD026987 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI EL FAKHRI, GEORGES · 2020 to 2020
$593k
NIBIB NIH HHS P41 EB022544NIBIB NIH HHS P41EB022544NIDDK NIH HHS P30 DK040561NIH HHS S10 OD026987NIH Office of the Director S10OD026987NINDS NIH HHS R01 NS114066NINDS NIH HHS R01NS114066
6 · The paper itself

Abstract

purpose[

methodsFour healthy volunteers (2 females) underwent a 4-h dynamic PET scan from the cranial vertex to mid-thigh using multiple bed positions after administration of 368 ± 17.9 MBq (9.94 ± 0.48 mCi) of [

results[

conclusionThe biodistribution and radiation dosimetry of [

Indexed as

Demyelinating DiseasesRadiometryAnimalsFemaleFluorine RadioisotopesHumansMalePositron-Emission TomographyRadiopharmaceuticalsTissue DistributionFluorine-18Fluorine RadioisotopesRadiopharmaceuticals[18F]3F4AP4-AminopyridineBiodistributionDemyelinationFirst in humanFluorine-18INDMultiple sclerosisPETRadiation dosimetryVoltage-gated potassium channels

Identifiers

PMID36197499
PMCPMC9816249
OpenAlexW4301394025

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.