SynthesisEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology2022
Outcomes of isolated tricuspid valve replacement: a systematic review and meta-analysis of 5,316 patients from 35 studies.
Synthesis in EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Long-term outcomes with medical therapy, transcatheter repair, or surgery for isolated tricuspid regurgitation: a systematic review and network meta-analysis.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Pooled it
- Comparative analysis of MitraClip/TriClip and PASCAL in transcatheter tricuspid valve repair for tricuspid regurgitation: a systematic review and meta-analysis.BMC cardiovascular disorders · 2024Pooled it
- Sinus rhythm restoration reverses tricuspid regurgitation in patients with atrial fibrillation: a systematic review and meta-analysis.Journal of cardiothoracic surgery · 2024Pooled it
- Leadless Pacing for Delayed Heart Block After Transcatheter Tricupid Valve Replacement.JACC. Case reports · 2026Article
- Four-year clinical and echocardiographic outcomes after tricuspid valve replacement using a novel bovine pericardial valve bioprosthesis.JTCVS open · 2026Article
- Contemporary insights and evolving clinical pathways in transcatheter tricuspid valve replacement.Herz · 2026Review
- The current state of isolated tricuspid valve surgery: how it complements transcatheter tricuspid valve interventions.Annals of cardiothoracic surgery · 2026Review
- Three decades evolution of the lifetime management approach to tricuspid valve disease: a multidisciplinary European perspective from a high-volume heart valve center.Annals of cardiothoracic surgery · 2026Article
- Innovations in transcatheter tricuspid valve interventions: what has failed, what has worked, what is coming.Annals of cardiothoracic surgery · 2026Review
- Acute Impact of Transcatheter Edge-to-Edge Repair of Tricuspid Regurgitation on Right Ventricular Hemodynamics.Journal of the American Heart Association · 2026Article
- Isolated secondary tricuspid regurgitation after left-sided valve surgery: impact on clinical outcomes.Open heart · 2026Observational
- A Novel Minimally Invasive Porcine Model of Functional Tricuspid Regurgitation.Journal of cardiovascular development and disease · 2026Article
- Navigating isolated tricuspid regurgitation: A practical guide to perioperative and periprocedural management.JTCVS open · 2026Article
- Transcatheter and surgical management of tricuspid valve disease: multidisciplinary lifetime management considerations.Annals of cardiothoracic surgery · 2026Review
- Congenital Tricuspid Valve Cleft Diagnosis Several Years after Pulmonary Valve Intervention.CASE (Philadelphia, Pa.) · 2026Article
- Deep learning model for identifying significant tricuspid regurgitation using standard 12-lead electrocardiogram.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Patient Selection for Transcatheter Tricuspid Valve Intervention: Not Too Early, Not Too Late.Structural heart : the journal of the Heart Team · 2026Review
- Review
- Revisiting tricuspid regurgitation: Historical insights and emerging research perspectives.European journal of clinical investigation · 2026Review
- Management of Tricuspid Valve Regurgitation Consensus Recommendations.Heart views : the official journal of the Gulf Heart Association · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTranscatheter tricuspid valve replacement (TTVR) is rapidly emerging as a therapeutic option amongst patients with secondary tricuspid regurgitation. Historical data from surgical tricuspid valve replacement (TVR) studies may serve as a benchmark for the development of TTVR trials.
aimsThe aim of the study was to investigate the early and late outcomes following isolated surgical TVR.
methodsMultiple electronic databases were searched to identify studies on isolated surgical TVR. The prespecified primary endpoint was operative mortality; secondary endpoints were early and late outcomes. Overall estimates of proportions and incidence rates with 95% confidence intervals (CI) were calculated using random-effects models. Multiple sensitivity analyses accounting for baseline characteristics, country and the operative period were applied. Results: A total of 35 studies (5,316 patients) were included in this meta-analysis. The operative period ranged from 1974 to 2019. The overall rate of operative mortality was 12% (95% CI: 9-15), with higher mortality for patients who were operated on before 1995, who had prior cardiac surgeries, or who had liver disease. The most frequent clinical events were pacemaker implantation (10% [95% CI: 6-16]), bleeding (12% [95% CI: 8-17]), acute kidney injury (15% [95% CI: 9-24]) and respiratory complications (15% [95% CI: 12-20]). At follow-up analysis of the bioprosthetic TVR, there was an incidence rate per 100 person-years of 6 (95% CI: 2-13) for death and 8 (95% CI: 5-13) for recurrence of significant tricuspid regurgitation.
conclusionsThis meta-analysis provides an overview of the historical clinical outcomes following isolated surgical TVR. These findings can support the development of future clinical trials in the tricuspid space by providing thresholds for clinical outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.