Evidence map›Paper›PMID 36197191›Full record

Observational studyMedicine2022

Blood pressure variability related to early outcome of acute ischemia stroke in a prospective observational study.

Wang Ningning, Hu Ying, Lin Shudong, Zhang Zhilong, Cai Qibo, Deng Yuting, Zhang Hao, Wu Nan, Qiu Changchun, Yang Xiujing and 2 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Wang NingningInstitute of Polygenic Disease, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Hu YingInstitute of Polygenic Disease, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Lin ShudongThe Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Zhang ZhilongThe Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Cai QiboThe Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Deng YutingThe Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Zhang HaoInstitute of Polygenic Disease, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Wu NanInstitute of Polygenic Disease, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Qiu ChangchunInstitute of Polygenic Disease, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Yang XiujingThe Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Jin MingInstitute of Polygenic Disease, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Li JingpingInstitute of Polygenic Disease, Qiqihar Medical University, Qiqihar, Heilongjiang, China.ORCID 0000-0003-4968-2615
Qiqihar Medical University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNS.P.E.C.I.E.S. · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypertension is a well-known risk factor for stroke, but the relationship between blood pressure variation (BPV) and prognosis remains unclear. This prospective observational study assessed the association between BPV and early functional outcomes in acute ischemic stroke patients. A total of 871 patients with acute ischemic stroke within 24 h of symptom onset were recruited from the Third Affiliated Hospital of Qiqihar Medical University between 2013 and 2016. Within 6 days of hospitalization, blood pressure was continuously measured from 8:00 to 9:00 every day, and the coefficient of variation (CV) of blood pressure was calculated (including systolic blood pressure [SBP] and diastolic blood pressure [DBP]). The modified Rankin scale was used to evaluate early functional outcomes at discharge. The coefficients of variation of SBP, DBP, and functional outcomes were included as primary outcome variables. Demographic characteristics and medical history were recorded as secondary outcome variables. We found that a greater CV level of SBP and DBP were associated with the poor early functional outcome at hospital discharge, and the odds ratio (OR) and 95% confidence interval (95%CI) of them were 1.56 (1.04-2.35) and 1.99 (1.31-3.03) respectively. A higher standard deviation (SD) of SBP and DBP significantly increased risk of poor early prognosis, OR (95%CI) was 1.78 (1.17-2.71) and 2.25 (1.47-3.45) respectively. Similar results were observed for SBP and DBP. The larger the range of SBP and DBP, the worse is the prognosis. In conclusion, the present study suggests that high BPV is a risk factor for poor early prognosis in acute ischemic stroke.

Indexed as

HypertensionIschemic StrokeStrokeBlood PressureBlood Pressure DeterminationHumansIschemia

Identifiers

PMID36197191
PMCPMC9509110
OpenAlexW4297019834

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.