ArticleDNA research : an international journal for rapid publication of reports on genes and genomes2022
De novo genome assembly of the medicinal plant Gentiana macrophylla provides insights into the genomic evolution and biosynthesis of iridoids.
Article in DNA research : an international journal for rapid publication of reports on genes and genomes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 46 citations in OpenAlex.
- The Gentiana rigescens genome and transcriptome for the investigation of flower repetitive blooming.BMC biology · 2025Article
- Metabolic Engineering of Terpenoid Biosynthesis in Medicinal Plants: From Genomic Insights to Biotechnological Applications.Current issues in molecular biology · 2025Review
- Conservation Genomics for Threatened New ZealandEcology and evolution · 2025Article
- Genome-wide identification and transcriptional expression profiles of the transcription factor WRKY in Gentiana macrophylla.Molecular biology reports · 2025Article
- Insights from the first chromosome-level genome assembly of the alpine gentian Gentiana straminea Maxim.DNA research : an international journal for rapid publication of reports on genes and genomes · 2024Article
- Transcriptome and metabolome analysis reveals mechanism of light intensity modulating iridoid biosynthesis in Gentiana macrophylla Pall.BMC plant biology · 2024Article
- Genomic characterization of WRKY transcription factors related to secoiridoid biosynthesis in Gentiana macrophylla.BMC plant biology · 2024Article
- Monoterpene glucosides in Eustoma grandiflorum roots promote hyphal branching in arbuscular mycorrhizal fungi.Plant physiology · 2023Article
- Terpenoid Glucosides fromMolecules (Basel, Switzerland) · 2023Article
- Article
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Authors and funding
6 authors at 6 institutions in 2 countries.
Funding
Abstract
Gentiana macrophylla is a perennial herb in the Gentianaceae family, whose dried roots are used in traditional Chinese medicine. Here, we assembled a chromosome-level genome of G. macrophylla using a combination of Nanopore, Illumina, and Hi-C scaffolding approaches. The final genome size was ~1.79 Gb (contig N50 = 720.804 kb), and 98.89% of the genome sequences were anchored on 13 pseudochromosomes (scaffold N50 = 122.73 Mb). The genome contained 55,337 protein-coding genes, and 73.47% of the assemblies were repetitive sequences. Genome evolution analysis indicated that G. macrophylla underwent two rounds of whole-genome duplication after the core eudicot γ genome triplication event. We further identified candidate genes related to the biosynthesis of iridoids, and the corresponding gene families mostly expanded in G. macrophylla. In addition, we found that root-specific genes are enriched in pathways involved in defense responses, which may greatly improve the biological adaptability of G. macrophylla. Phylogenomic analyses showed a sister relationship of asterids and rosids, and all Gentianales species formed a monophyletic group. Our study contributes to the understanding of genome evolution and active component biosynthesis in G. macrophylla and provides important genomic resource for the genetic improvement and breeding of G. macrophylla.
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