Evidence map›Paper›PMID 36197094›Full record

ArticleAntimicrobial agents and chemotherapy2022

Disulfiram Is Effective against Drug-Resistant Mycobacterium abscessus in a Zebrafish Embryo Infection Model.

Carlynn G Winters, Ram M Basnet, Paige E Faasuamalie, Shamira J Shallom, Adrian M Zelazny, Shashank Gupta, Kenneth N Olivier

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Zebrafish larvae swim bladder serves as a model to studyMycobacteria (London, England) · 2026
    Article
  2. Review
  3. Antibacterial activity of the novel compound Sudapyridine (WX-081) againstFrontiers in cellular and infection microbiology · 2023
    Article
  4. Antibacterial activity of the novel oxazolidinone contezolid (MRX-I) againstFrontiers in cellular and infection microbiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Carlynn G Winters *Laboratory of Chronic Airway Infection, Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.
Ram M Basnet *Laboratory of Chronic Airway Infection, Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.
Paige E FaasuamalieLaboratory of Chronic Airway Infection, Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.
Shamira J ShallomDepartment of Laboratory Medicine, Clinical Center, National Institutes of Healthgrid.94365.3d, Bethesda, Maryland, USA.
Adrian M ZelaznyDepartment of Laboratory Medicine, Clinical Center, National Institutes of Healthgrid.94365.3d, Bethesda, Maryland, USA.ORCID 0000-0003-2847-7428
Shashank Gupta *Laboratory of Chronic Airway Infection, Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.
Kenneth N Olivier *Laboratory of Chronic Airway Infection, Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.ORCID 0000-0001-8200-255X
National Heart Lung and Blood Institute · USNational Institutes of Health Clinical Center · US

Funding

HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) 1ZIAHL006200HHS | NIH | NIH Clinical Center (CC) 1ZIACL080012
6 · The paper itself

Abstract

Mycobacterium abscessus is an emerging nontuberculous mycobacterium (NTM) pathogen infecting susceptible people with cystic fibrosis (CF) and non-CF bronchiectasis. Here, we demonstrated the activity of an FDA-approved drug, disulfiram, against drug-susceptible and drug-resistant M. abscessus strains utilizing

Indexed as

Cystic FibrosisMycobacterium abscessusMycobacterium Infections, NontuberculousAnimalsDisulfiramHumansNontuberculous MycobacteriaZebrafishDisulfiramdisulfiramdrug resistantMycobacterium abscessuszebrafish

Identifiers

PMID36197094
PMCPMC9664858
OpenAlexW4302028353

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.