Evidence map›Paper›PMID 36197079›Full record

ArticleHuman vaccines & immunotherapeutics2022

Anamnestic broadly reactive antibodies induced by H7N9 virus more efficiently bind to seasonal H3N2 strains.

Yao Chen, Shannon P Hilchey, Jiong Wang, Jessica Garigen, Martin S Zand, Junqiong Huang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human vaccines & immunotherapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Yao ChenDepartment of Blood Transfusion, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Shannon P HilcheyDepartment of Medicine, Division of Nephrology, University of Rochester Medical Center, Rochester, NY, USA.
Jiong WangDepartment of Medicine, Division of Nephrology, University of Rochester Medical Center, Rochester, NY, USA.
Jessica GarigenDepartment of Medicine, Division of Nephrology, University of Rochester Medical Center, Rochester, NY, USA.
Martin S ZandDepartment of Medicine, Division of Nephrology, University of Rochester Medical Center, Rochester, NY, USA.
Junqiong HuangDepartment of Blood Transfusion, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.ORCID 0000-0001-6526-4179
University of Rochester Medical Center · USZunyi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The very first influenza virus exposure in a human during infancy is known to imprint the host immune system. However, it is unclear how the memory B cells that first target virus epitopes affect antibody response to the stalk of hemagglutinin (HA) domain of influenza virus. Our study is designed to measure the cross-reactivity of antibodies induced by inactivated H7N9 virus using isolated human peripheral blood B cells. Most of the participants displayed higher levels of plasma IgG against the seasonal strains A/Vic11 and A/Cali09 than those binding to historical outbreak A/HK68 and A/PR8. H3 stalk-binding antibodies were detected in plasma at a 1:5000 dilution in 12 of 13 donors, H1 stalk-binding antibodies in all donors, indicating the existence of H3 and H1 stalk-reactive memory B cells. A moderate to high level of broadly cross-reactive antibodies was induced in memory B cells from all donors after

Indexed as

Influenza A Virus, H1N1 SubtypeInfluenza A Virus, H7N9 SubtypeInfluenza, HumanInfluenza VaccinesAntibodies, ViralHemagglutinin Glycoproteins, Influenza VirusHemagglutininsHumansImmunoglobulin GInfluenza A Virus, H3N2 SubtypeAntibodies, ViralHemagglutinin Glycoproteins, Influenza VirusHemagglutininsImmunoglobulin GInfluenza Vaccinescross-reactive antibodyH7N9 viruseshemagglutinin stalkInfluenzamemory B cells

Identifiers

PMID36197079
PMCPMC9746487
OpenAlexW4301606012

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.