Evidence map›Paper›PMID 36196802›Full record

ArticleNMR in biomedicine2023

Impact of gradient scheme and non-linear shimming on out-of-voxel echo artifacts in edited MRS.

Yulu Song, Helge J Zöllner, Steve C N Hui, Kathleen E Hupfeld, Georg Oeltzschner, Richard A E Edden

Open access · greenAbstract read
In one paragraph

Article in NMR in biomedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Brain glutathione and GABA+ levels in autistic children.Autism research : official journal of the International Society for Autism Research · 2024
    Article
  6. Application of aImaging neuroscience (Cambridge, Mass.) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yulu SongRussell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Helge J ZöllnerRussell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-7148-292X
Steve C N HuiRussell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-1523-4040
Kathleen E HupfeldRussell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Georg OeltzschnerRussell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-3083-9811
Richard A E EddenRussell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Kennedy Krieger Institute · US

Funding

TR&D 4: Algorithms for functional and anatomical brain analysisP41EB015909 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2012 to 2020
$13.1M
Universal GABA-edited MRS at 3TR01EB016089 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Richard Anthony Edward Edden · 2013 to 2026
$5.4M
Simultaneous Hadamard Editing of GABA and GlutathioneR01EB023963 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI EDDEN, RICHARD ANTHONY EDWARD · 2017 to 2024
$3.8M
Towards a comprehensive neurometabolic profile in patients with mild cognitive impairment.R00AG062230 · NIA · JOHNS HOPKINS UNIVERSITY · PI OELTZSCHNER, GEORG · 2021 to 2023
$735k
Neurometabolic profile of mild cognitive impairment using multiplexed edited MRSR21AG060245 · NIA · JOHNS HOPKINS UNIVERSITY · PI EDDEN, RICHARD ANTHONY EDWARD · 2018 to 2019
$466k
Cortical Inhibition and Mobility in Older AdultsK00AG068440 · NIA · JOHNS HOPKINS UNIVERSITY · PI HUPFELD, KATHLEEN ELIZABETH · 2022 to 2024
$222k
NIA NIH HHS K00 AG068440NIA NIH HHS R00 AG062230NIA NIH HHS R21 AG060245NIBIB NIH HHS P41 EB015909NIBIB NIH HHS R01 EB016089NIBIB NIH HHS R01 EB023963
6 · The paper itself

Abstract

Out-of-voxel (OOV) signals are common spurious echo artifacts in MRS. These signals often manifest in the spectrum as very strong "ripples," which interfere with spectral quantification by overlapping with targeted metabolite resonances. Dephasing optimization through coherence order pathway selection (DOTCOPS) gradient schemes are algorithmically optimized to suppress all potential alternative coherence transfer pathways (CTPs), and should suppress unwanted OOV echoes. In addition, second-order shimming uses non-linear gradient fields to maximize field homogeneity inside the voxel, which unfortunately increases the diversity of local gradient fields outside of the voxel. Given that strong local spatial B

Indexed as

ArtifactsBraingamma-Aminobutyric AcidHeadHumansMagnetic Resonance Spectroscopygamma-Aminobutyric Acidcoherence transfer pathway (CTP)DOTCOPSGABAGSHHERMESout of voxel (OOV)

Identifiers

PMID36196802
PMCPMC9845189
OpenAlexW4302004036

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.