Observational studyThe Journal of clinical endocrinology and metabolism2023
Intestinal Calcium Absorption Decreases After Laparoscopic Sleeve Gastrectomy Despite Optimization of Vitamin D Status.
Observational study in The Journal of clinical endocrinology and metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 25 citations in OpenAlex.
- Metabolic and Bariatric Surgery and Bone Mineral Density: A 9-Year Prospective Study.Obesity surgery · 2026Article
- Why Do We Lose Bone During Weight Loss: Can It Be Prevented?Current osteoporosis reports · 2026Review
- Predictive Effect of Preoperative Bone Marrow Fat Fraction on Postoperative Bone Mineral Density After Bariatric Surgery: a Prospective Cohort Study.Obesity surgery · 2026Article
- Hypocalcemia After Cervical Procedures in Patients with a History of Nonbariatric Gastrojejunostomy.Annals of surgical oncology · 2026Article
- Article
- Bariatric surgery: Think about osteomalacia too.Archives of osteoporosis · 2025Article
- Skeletal Effects of Sleeve Gastrectomy, by Sex and Menopausal Status and Compared to Roux-En-Y Gastric Bypass Surgery.The Journal of clinical endocrinology and metabolism · 2025Observational
- Association between dietary zinc intake amount and prevalence of osteoporosis in middle-aged and elderly individuals: a cross-sectional study.Irish journal of medical science · 2025Article
- Management of Adverse Skeletal Effects Following Bariatric Surgery Procedures in People Living with Obesity.Current osteoporosis reports · 2025Review
- A Nomogram for Predicting Secondary Hyperparathyroidism after Bariatric Surgery: A Retrospective Study on Short-Term Outcome.Obesity surgery · 2025Article
- Nutritional Challenges and Treatment After Bariatric Surgery.Annual review of nutrition · 2024Review
- Skeletal effects of sleeve gastrectomy, by sex and menopausal status and in comparison to Roux-en-Y gastric bypass surgery.medRxiv : the preprint server for health sciences · 2024Article
- Alteration in the gut microbiome is associated with changes in bone metabolism after laparoscopic sleeve gastrectomy.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Obesity and Skeletal Fragility.The Journal of clinical endocrinology and metabolism · 2024Review
- Dynamic Evaluation of Vitamin D Metabolism in Post-Bariatric Patients.Journal of clinical medicine · 2023Article
- Observational
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14 authors at 6 institutions in 1 country.
Funding
Abstract
contextLaparoscopic sleeve gastrectomy (LSG), now the most commonly performed bariatric operation, is a highly effective treatment for obesity. While Roux-en-Y gastric bypass is known to impair intestinal fractional calcium absorption (FCA) and negatively affect bone metabolism, LSG's effects on calcium homeostasis and bone health have not been well characterized.
objectiveWe determined the effect of LSG on FCA, while maintaining robust 25-hydroxyvitamin D (25OHD) levels and recommended calcium intake. DESIGN, SETTING,
participantsProspective pre-post observational cohort study of 35 women and men with severe obesity undergoing LSG. MAIN OUTCOMES: FCA was measured preoperatively and 6 months postoperatively with a gold-standard dual stable isotope method. Other measures included calciotropic hormones, bone turnover markers, and bone mineral density (BMD) by dual-energy X-ray absorptiometry and quantitative computed tomography.
resultsMean ± SD FCA decreased from 31.4 ± 15.4% preoperatively to 16.1 ± 12.3% postoperatively (P < 0.01), while median (interquartile range) 25OHD levels were 39 (32-46) ng/mL and 36 (30-46) ng/mL, respectively. Concurrently, median 1,25-dihydroxyvitamin D level increased from 60 (50-82) pg/mL to 86 (72-107) pg/mL (P < 0.01), without significant changes in parathyroid hormone or 24-hour urinary calcium levels. Bone turnover marker levels increased substantially, and areal BMD decreased at the proximal femur. Those with lower postoperative FCA had greater areal BMD loss at the total hip (ρ = 0.45, P < 0.01).
conclusionsFCA decreases after LSG, with a concurrent rise in bone turnover marker levels and decline in BMD, despite robust 25OHD levels and with recommended calcium intake. Decline in FCA could contribute to negative skeletal effects following LSG.
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