Evidence map›Paper›PMID 36196502›Full record

ArticleThe Journal of infectious diseases2023

Primary Anal Cancer Screening Results From 381 Women With Human Immunodeficiency Virus.

Yuxin Liu, Kevin Weiss, Andrés Ramírez Zamudio, Monica Prasad Hayes, Mona Saleh, Michael M Gaisa, Keith Sigel

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yuxin LiuDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Kevin WeissIcahn School of Medicine at Mount Sinai, New York, New York, USA.
Andrés Ramírez ZamudioDepartment of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Monica Prasad HayesDepartment of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Mona SalehDepartment of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Michael M GaisaDivision of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Keith SigelDivision of General Internal Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0002-4051-4861
Icahn School of Medicine at Mount Sinai · US

Funding

The effectiveness of screening women with lower genital tract neoplasia or cancers for anal cancer precursorsR01CA256660 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHIAO, ELIZABETH Y., DESHMUKH, ASHISH A. · 2021 to 2025
$4.3M
NCI NIH HHS R01 CA256660NCI NIH HHS R01CA256660
6 · The paper itself

Abstract

backgroundWomen with human immunodeficiency virus (WWH) have an elevated risk for human papillomavirus (HPV)-associated anal cancer. Primary anal cancer screening results from this population could inform practice guidelines.

methodsIn total, 381 WWH with anal cytology screening, high-risk HPV (hrHPV) testing and genital (cervical or vaginal) cotesting within 6 months were identified during 2012-2019. Those with anal cytology of atypical squamous cells of undetermined significance (ASCUS) or worse underwent high-resolution anoscopy and biopsy. Independent predictors of anal hrHPV, HPV16, and histological anal high-grade squamous intraepithelial lesions (aHSIL) were identified using adjusted logistic regression models.

resultsPrevalence of anal hrHPV, HPV16, and ASCUS or worse cytology was 61%, 13%, and 68%. Histological aHSIL was detected in 42% of WWH with ASCUS or worse anal cytology. Prevalence of genital hrHPV, HPV16, and ASCUS or worse cytology was 30%, 4%, and 28%. Genital hrHPV predicted anal hrHPV (odds ratio [OR], 5.05), while genital HPV16 predicted anal HPV16 (OR, 9.52). Genital hrHPV and anal HPV16 predicted histological aHSIL (ORs, 2.78 and 10.9).

conclusionsAnal HPV disease was highly prevalent in this primary screening cohort of WWH. While genital screening results predicted anal disease, rates of isolated anal HPV disease were substantial, supporting universal anal cancer screening for this population.

Indexed as

Atypical Squamous Cells of the CervixPapillomavirus InfectionsUterine Cervical NeoplasmsEarly Detection of CancerFemaleHIVHuman papillomavirus 16Human Papillomavirus VirusesHumansPapillomaviridaeanal cancer screeninghuman papillomaviruswomen with human immunodeficiency virus

Identifiers

PMID36196502
PMCPMC10319954
OpenAlexW4301430896

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.